Evidence map›Paper›PMID 34306007›Full record

ArticleFrontiers in genetics2021

Whole-Genome Resequencing to Study Brucellosis Susceptibility in Sheep.

Xiaolong Li, Qingmin Wu, Xiaoxue Zhang, Chong Li, Deyin Zhang, Guoze Li, Yukun Zhang, Yuan Zhao, Zhaoguo Shi, Weimin Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Genomic insights into the recent evolution and biodiversity of Italian sheep breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Genomic Inbreeding and Runs of Homozygosity Analysis of Cashmere Goat.Animals : an open access journal from MDPI · 2024
    Article
  11. InvestigatingArchives animal breeding · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiaolong LiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Qingmin WuCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Xiaoxue ZhangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Chong LiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Deyin ZhangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Guoze LiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Yukun ZhangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Yuan ZhaoCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Zhaoguo ShiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Weimin WangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Fadi LiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.
Gansu Agricultural University · CNChina Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brucellosis is a zoonotic disease and a major public health problem. However, the genetic mechanism of brucellosis in sheep remains unclear. In this study, serum samples were collected from 6,358 sheep from the F2 population (Dorper sheep ♂ × Hu sheep ♀), and antibody levels were continuously measured at 14 days and 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 months after administration of brucellosis vaccine. Finally, 19 brucellosis-resistant group (BRG) sheep and 22 brucellosis-susceptible group sheep (BSG) were screened for whole-genome sequencing. Using the fixation index, Fisher's exact test, and chi-square test, a total of 205 candidate SNP sites were identified. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis suggested that 138 candidate genes were significantly enriched in adherens junction (

Indexed as

brucellosischi-square testFisher’s exact testFSTsheepwhole-genome resequencing

Identifiers

PMID34306007
PMCPMC8297390
OpenAlexW3180174321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.