Evidence map›Paper›PMID 34305943›Full record

Trial reportFrontiers in immunology2021

Non-HLA Antibodies and Epitope Mismatches in Kidney Transplant Recipients With Histological Antibody-Mediated Rejection.

Marta Crespo, Laura Llinàs-Mallol, Dolores Redondo-Pachón, Carrie Butler, Javier Gimeno, María José Pérez-Sáez, Carla Burballa, Anna Buxeda, Carlos Arias-Cabrales, Montserrat Folgueiras and 4 more

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
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  5. Review
  6. Article
  7. Sensitization in Transplantation Assessment of Risk 2025 innate working group: The potential role of innate allorecognition in kidney allograft damage.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Review
  8. Article
  9. Article
  10. Article
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  12. Autoantibodies against DNA topoisomerase I promote renal allograft rejection by increasing alloreactive T cell responses.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Article
  13. Article
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  20. Molecular diagnosis of ABMR with or without donor-specific antibody in kidney transplant biopsies: Differences in timing and intensity but similar mechanisms and outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Marta CrespoDepartment of Nephrology, Hospital del Mar, Barcelona, Spain.
Laura Llinàs-MallolDepartment of Nephrology, Hospital del Mar, Barcelona, Spain.
Dolores Redondo-PachónDepartment of Nephrology, Hospital del Mar, Barcelona, Spain.
Carrie ButlerUCLA Immunogenetics Center, University of California Los Angeles, Los Angeles, CA, United States.
Javier GimenoHospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
María José Pérez-SáezDepartment of Nephrology, Hospital del Mar, Barcelona, Spain.
Carla BurballaDepartment of Nephrology, Hospital del Mar, Barcelona, Spain.
Anna BuxedaDepartment of Nephrology, Hospital del Mar, Barcelona, Spain.
Carlos Arias-CabralesDepartment of Nephrology, Hospital del Mar, Barcelona, Spain.
Montserrat FolgueirasDepartment of Nephrology, Hospital del Mar, Barcelona, Spain.
Sara Sanz-UreñaDepartment of Nephrology, Hospital del Mar, Barcelona, Spain.
Nicole M ValenzuelaUCLA Immunogenetics Center, University of California Los Angeles, Los Angeles, CA, United States.
Elaine F ReedUCLA Immunogenetics Center, University of California Los Angeles, Los Angeles, CA, United States.
Julio PascualDepartment of Nephrology, Hospital del Mar, Barcelona, Spain.
Hospital del Mar Research Institute · ESHospital Del Mar · ESUniversity of California, Los Angeles · US

Funding

The role of HLA and its coreceptors in endothelial cell activation and leukocyte recruitment in antibody-mediated transplant rejectionR01AI135201 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert L Fairchild, ELAINE F REED · 2018 to 2026
$5.3M
NIAID NIH HHS R01 AI135201
6 · The paper itself

Abstract

Background: Correlation between antibody-mediated rejection (ABMR) and circulating HLA donor-specific antibodies (HLA-DSA) is strong but imperfect in kidney transplant (KT) recipients, raising the possibility of undetected HLA-DSA or non-HLA antibodies contributing to ABMR. Detailed evaluation of the degree of HLA matching together with the identification of non-HLA antibodies in KT may help to decipher the antibody involved. Methods: We retrospectively assessed patients with transplant biopsies scored following Banff'15 classification. Pre- and post-transplant serum samples were checked for HLA and non-HLA antibodies [MICA-Ab, angiotensin-II type-1-receptor (AT Results: One-hundred eighteen patients with normal histology (n = 19), ABMR Conclusions: In conclusion, pre-transplant AT

Indexed as

Antibody SpecificityKidney TransplantationAdultEpitopesFemaleGraft RejectionHLA AntigensHumansIsoantibodiesMaleMiddle AgedEpitopesHLA AntigensIsoantibodiesantibody-mediated rejectionAT1R antibodiesHLA antibodiesHLA epitope mismatchkidney transplantationnon-HLA antibodies

Identifiers

PMID34305943
PMCPMC8300190
OpenAlexW3179008577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.