Evidence map›Paper›PMID 34305930›Full record

ArticleFrontiers in immunology2021

Auto-Antibody Production During Experimental Atherosclerosis in

Mark A Hutchinson, Han-Sol Park, Kimberly J Zanotti, Juan Alvarez-Gonzalez, Jing Zhang, Li Zhang, Richard Telljohann, Mingyi Wang, Edward G Lakatta, Patricia J Gearhart and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. A bibliometric analysis of vaccination against atherosclerosis.Human vaccines & immunotherapeutics · 2024
    Article
  7. Review
  8. T-Cell/B-Cell Interactions in Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  9. Atherosclerosis antigens as targets for immunotherapy.Nature cardiovascular research · 2023
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Mark A HutchinsonLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, United States.
Han-Sol ParkLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, United States.
Kimberly J ZanottiLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, United States.
Juan Alvarez-GonzalezLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, United States.
Jing ZhangLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, United States.
Li ZhangLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, United States.
Richard TelljohannLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, United States.
Mingyi WangLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, United States.
Edward G LakattaLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD, United States.
Patricia J GearhartLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, United States.
Robert W MaulLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, United States.
National Institute on Aging · US

Funding

Effect of Age on Antibody DiversityZIAAG000777 · NIA · NATIONAL INSTITUTE ON AGING · PI GEARHART, PATRICIA J · 2012 to 2025
$12.6M
Progression of Arterial Aging: the Local MCP-1/MMP-2/TGF-beta 1 Signaling LoopZIAAG000240 · NIA · NATIONAL INSTITUTE ON AGING · PI WANG, MINGYI · 2009 to 2025
$4.6M
Effects of Aging on Experimental Atherosclerosis in Nonhuman PrimatesZIAAG000238 · NIA · NATIONAL INSTITUTE ON AGING · PI LAKATTA, EDWARD · 2009 to 2025
$4.5M
Effect on Metalloprotease Inhibition on Age-Associated Arterial RemodelingZIAAG000239 · NIA · NATIONAL INSTITUTE ON AGING · PI LAKATTA, EDWARD · 2009 to 2025
$4.3M
Calpain-1 Activity and Central Arterial AgingZIAAG000236 · NIA · NATIONAL INSTITUTE ON AGING · PI LAKATTA, EDWARD · 2009 to 2025
$3.6M
6 · The paper itself

Abstract

Current models stipulate that B cells and antibodies function during atherosclerosis in two distinct ways based on antibody isotype, where IgM is protective and IgG is inflammatory. To examine this model, we generated

Indexed as

AutoimmunityAICDA (Activation-Induced Cytidine Deaminase)AnimalsAntibody FormationAtherosclerosisAutoantibodiesB-LymphocytesCholesterolCytidine DeaminaseDisease Models, AnimalImmunoglobulin GImmunoglobulin MLipoproteins, LDLMaleMalondialdehydeMiceAICDA (Activation-Induced Cytidine Deaminase)AutoantibodiesCholesterolCytidine DeaminaseImmunoglobulin GImmunoglobulin MLipoproteins, LDLMalondialdehydemalondialdehyde-low density lipoprotein, mouseAIDantibodiesantigensatherosclerosisB cells

Identifiers

PMID34305930
PMCPMC8299997
OpenAlexW3181390360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.