Evidence map›Paper›PMID 34305923›Full record

ArticleFrontiers in immunology2021

Identification and Immune Assessment of T Cell Epitopes in Five

Vinayaka Kotraiah, Timothy W Phares, Frances E Terry, Pooja Hindocha, Sarah E Silk, Carolyn M Nielsen, Leonard Moise, Kenneth D Tucker, Rebecca Ashfield, William D Martin and 4 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Genetic variation of theFrontiers in parasitology · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Host-parasite interactions duringFrontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Vinayaka KotraiahLeidos Life Sciences, Leidos Inc., Frederick, MD, United States.
Timothy W PharesLeidos Life Sciences, Leidos Inc., Frederick, MD, United States.
Frances E TerryEpiVax Inc., Providence, RI, United States.
Pooja HindochaEpiVax Inc., Providence, RI, United States.
Sarah E SilkThe Jenner Institute, University of Oxford, Oxford, United Kingdom.
Carolyn M NielsenThe Jenner Institute, University of Oxford, Oxford, United Kingdom.
Leonard MoiseEpiVax Inc., Providence, RI, United States.
Kenneth D TuckerLeidos Life Sciences, Leidos Inc., Frederick, MD, United States.
Rebecca AshfieldThe Jenner Institute, University of Oxford, Oxford, United Kingdom.
William D MartinEpiVax Inc., Providence, RI, United States.
Anne S De GrootEpiVax Inc., Providence, RI, United States.
Simon J DraperThe Jenner Institute, University of Oxford, Oxford, United Kingdom.
Gabriel M GutierrezLeidos Life Sciences, Leidos Inc., Frederick, MD, United States.
Amy R NoeLeidos Life Sciences, Leidos Inc., Frederick, MD, United States.
Leidos (United States) · USEpiVax (United States) · USJenner Institute · GBProvidence College · USUniversity of Oxford · GB

Funding

Wellcome Trust 106917/Z/15/ZWellcome Trust 209200/Z/17/Z
6 · The paper itself

Abstract

The hurdles to effective blood stage malaria vaccine design include immune evasion tactics used by the parasite such as redundant invasion pathways and antigen variation among circulating parasite strains. While blood stage malaria vaccine development primarily focuses on eliciting optimal humoral responses capable of blocking erythrocyte invasion, clinically-tested

Indexed as

Antigens, ProtozoanCarrier ProteinsCD4-Positive T-LymphocytesEpitopes, T-LymphocyteHLA-DR AntigensHost-Parasite InteractionsHumansInterferon-gammaMalaria, FalciparumMalaria VaccinesPlasmodium falciparumProtozoan ProteinsAntigens, ProtozoanCarrier ProteinsCyRPA protein, Plasmodium falciparumEpitopes, T-Lymphocyteerythrocyte-binding antigen 175, PlasmodiumHLA-DR AntigensIFNG protein, humanInterferon-gammaMalaria VaccinesProtozoan ProteinsRH5 protein, Plasmodium falciparumRipr protein, Plasmodium falciparumAMA1class II T cell epitopeCyRPAEBA175malariaRH5RIPRVAC063

Identifiers

PMID34305923
PMCPMC8294059
OpenAlexW3180162313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.