Evidence map›Paper›PMID 34305917›Full record

ArticleFrontiers in immunology2021

BHLHE40 Regulates IL-10 and IFN-

Molly Javier Uyeda, Robert A Freeborn, Brandon Cieniewicz, Rosa Romano, Ping Pauline Chen, Jeffrey Mao-Hwa Liu, Benjamin Thomas, Esmond Lee, Alma-Martina Cepika, Rosa Bacchetta and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  3. T-bet-expressing Tr1 cells driven by dietary signals dominate the small intestinal immune landscape.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Molly Javier UyedaDepartment of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.
Robert A FreebornDepartment of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.
Brandon CieniewiczDepartment of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.
Rosa RomanoDepartment of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.
Ping Pauline ChenDepartment of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.
Jeffrey Mao-Hwa LiuDepartment of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.
Benjamin ThomasDepartment of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.
Esmond LeeDepartment of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.
Alma-Martina CepikaDepartment of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.
Rosa BacchettaDepartment of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.
Maria Grazia RoncaroloDepartment of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.
Stanford Medicine · US

Funding

Training Program in Hematopoietic Cell TransplantationT32HL007952 · NHLBI · STANFORD UNIVERSITY · PI NEGRIN, ROBERT S · 2001 to 2021
$2.1M
Training in Pediatric Nonmalignant Hematology and Stem Cell BiologyT32DK098132 · NIDDK · STANFORD UNIVERSITY · PI SAKAMOTO, KATHLEEN M · 2014 to 2022
$1.9M
NHLBI NIH HHS T32 HL007952NIDDK NIH HHS T32 DK098132
6 · The paper itself

Abstract

Type 1 regulatory T (Tr1) cells are subset of peripherally induced antigen-specific regulatory T cells. IL-10 signaling has been shown to be indispensable for polarization and function of Tr1 cells. However, the transcriptional machinery underlying human Tr1 cell differentiation and function is not yet elucidated. To this end, we performed RNA sequencing on

Indexed as

Basic Helix-Loop-Helix ProteinsCell DifferentiationHomeodomain ProteinsHumansInterferon-gammaInterleukin-10Sequence Analysis, RNASignal TransductionT-Lymphocytes, RegulatoryTranscription FactorsBasic Helix-Loop-Helix ProteinsBHLHE40 protein, humanHomeodomain ProteinsInterferon-gammaInterleukin-10Transcription FactorscytokineregulatoryT celltranscription factortranscriptome

Identifiers

PMID34305917
PMCPMC8293608
OpenAlexW3180710505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.