Evidence map›Paper›PMID 34305900›Full record

ArticleFrontiers in immunology2021

Protective Role of Kynurenine 3-Monooxygenase in Allograft Rejection and Tubular Injury in Kidney Transplantation.

Randi Lassiter, Todd D Merchen, Xuexiu Fang, Youli Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Kynurenine Pathway after Kidney Transplantation: Friend or Foe?International journal of molecular sciences · 2024
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Randi LassiterDepartment of Surgery, Medical College of Georgia at Augusta University, Augusta, GA, United States.
Todd D MerchenDepartment of Surgery, Medical College of Georgia at Augusta University, Augusta, GA, United States.
Xuexiu FangDivision of Nephrology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States.
Youli WangDivision of Nephrology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States.
Augusta University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal tubular epithelial cells (TECs) are the primary targets of ischemia-reperfusion injury (IRI) and rejection by the recipient's immune response in kidney transplantation (KTx). However, the molecular mechanism of rejection and IRI remains to be identified. Our previous study demonstrated that kynurenine 3-monooxygenase (KMO) and kynureninase were reduced in ischemia-reperfusion procedure and further decreased in rejection allografts among mismatched pig KTx. Herein, we reveal that TEC injury in acutely rejection allografts is associated with alterations of Bcl2 family proteins, reduction of tight junction protein 1 (TJP1), and TEC-specific KMO. Three cytokines, IFN

Indexed as

Skin TransplantationAllograftsAnimalsCells, CulturedCytokinesEpithelial CellsFemaleGraft RejectionHumansInflammation MediatorsKidneyKynurenine 3-MonooxygenaseMiceMice, Inbred BALB CMice, Inbred C57BLPorcine Reproductive and Respiratory SyndromeBcl2 protein, mouseCytokinesInflammation MediatorsKynurenine 3-MonooxygenaseProto-Oncogene Proteins c-bcl-2Tjp1 protein, mouseZonula Occludens-1 Proteinallograft rejectionimmunosuppresantkidney transplantationkynurenine 3-monooxygenasekynurenine metabolism

Identifiers

PMID34305900
PMCPMC8293746
OpenAlexW3182933661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.