ArticleFrontiers in immunology2021
Global Transcriptomics Uncovers Distinct Contributions From Splicing Regulatory Proteins to the Macrophage Innate Immune Response.
Open access · goldAbstract read
In one paragraph
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- HnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing ofInfection and immunity · 2026Article
- hnRNPs in immunity: from nucleic acid sensing to lymphocyte fate determination.Frontiers in immunology · 2026Review
- HnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing ofbioRxiv : the preprint server for biology · 2025Article
- Alternatively spliced isoforms of IRF7 differentially regulate interferon expression to tune response to viral infection.Cell reports · 2025Article
- RNA processing in innate immunity: regulation by RNA-binding proteins.Trends in biochemical sciences · 2025Review
- ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA.Nucleic acids research · 2025Article
- Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice.iScience · 2025Article
- High throughput transcriptomics analysis of ovine mammary epithelial cells stimulated with Staphylococcus aureus in vitro.PloS one · 2025Article
- Functional and dynamic profiling of transcript isoforms reveals essential roles of alternative splicing in interferon response.Cell genomics · 2024Article
- PRPF40A induces inclusion of exons in GC-rich regions important for human myeloid cell differentiation.Nucleic acids research · 2024Article
- hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing.Molecular cell · 2024Article
- Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription.Cell reports · 2024Article
- What could be the function of the spinal muscular atrophy-causing protein SMN in macrophages?Frontiers in immunology · 2024Review
- Role of Heterogeneous Nuclear Ribonucleoproteins in the Cancer-Immune Landscape.International journal of molecular sciences · 2023Review
- SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX.eLife · 2022Article
- Article
- Transcriptional regulatory networks of circulating immune cells in type 1 diabetes: A community knowledgebase.iScience · 2022Article
- Article
- Article
- RNA regulatory mechanisms that control antiviral innate immunity.Immunological reviews · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Allison R WagnerDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health, Bryan, TX, United States.
Haley M ScottDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health, Bryan, TX, United States.
Kelsi O WestDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health, Bryan, TX, United States.
Krystal J VailDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health, Bryan, TX, United States.
Timothy C FitzsimonsDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health, Bryan, TX, United States.
Aja K ColemanDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health, Bryan, TX, United States.
Kaitlyn E CarterDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health, Bryan, TX, United States.
Robert O WatsonDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health, Bryan, TX, United States.
Kristin L PatrickDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health, Bryan, TX, United States.
Texas A&M Health Science Center · US
Funding
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MPre-mRNA splicing regulation is critical for controlling macrophage activationR35GM133720 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kristin Leigh Patrick · 2019 to 2026
$3.3MMitochondria as crucial regulators of innate immune outcomes during Mycobacterium tuberculosis infectionR01AI155621 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PATRICK, KRISTIN LEIGH, WATSON, ROBERT OWEN · 2021 to 2025
$2.9MTRIM proteins polarize DNA sensing outcomes during the innate immune response to Mycobacterium tuberculosisR01AI125512 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI WATSON, ROBERT OWEN · 2016 to 2019
$1.5MIMSD at Texas A&M University: Initiative for Maximizing Student Diversity in Biomedical SciencesT32GM135748 · NIGMS · TEXAS A&M UNIVERSITY · PI BRINKMEYER-LANGFORD, CANDICE L., CHIU, WEIHSUEH A · 2020 to 2024
$1.2MDiverse Predoctoral Training in GeneticsT32GM135115 · NIGMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ADELMAN, ZACH N. · 2020 to 2024
$901kNIAID NIH HHS R01 AI125512NIAID NIH HHS R01 AI155621NIGMS NIH HHS R35 GM133720NIGMS NIH HHS T32 GM135115NIGMS NIH HHS T32 GM135748NIH HHS P51 OD011104
Abstract
Pathogen sensing
Indexed as
Alternative SplicingGene Expression ProfilingGene Expression RegulationTranscriptomeAnimalsBiomarkersComputational BiologyGene OntologyGene Regulatory NetworksHeterogeneous-Nuclear RibonucleoproteinsHost-Pathogen InteractionsImmunity, InnateMacrophagesMaleMiceModels, BiologicalBiomarkersHeterogeneous-Nuclear RibonucleoproteinshnRNPinflammationpre-mRNA splicingRNA binding proteinSalmonella TyphimuriumSR protein
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.