Evidence map›Paper›PMID 34305815›Full record

SynthesisFrontiers in endocrinology2021

Preparation of the Endometrium for Frozen Embryo Transfer: A Systematic Review.

Sezcan Mumusoglu, Mehtap Polat, Irem Yarali Ozbek, Gurkan Bozdag, Evangelos G Papanikolaou, Sandro C Esteves, Peter Humaidan, Hakan Yarali

2 registry-linked trialsOpen access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06181305 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Hormonal Replacement Therapy Plus Letrozole Incorporation Versus Letrozole Mild Ovarian Stimulation in Endometrial Preparation for Frozen Embryo Transfer: A Randomised Controlled Trial

TypeinterventionalSponsorRahem Fertility CenterRan2024 to 2024Enrolled210ConditionsIVFArmsestradiol valerate and letrozole, letrozole 2,5 mg tablet
NCT06239376 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effectiveness of the Two Different Endometrial Preparation Regimes for Frozen Embryo Transfer in Patients With Adenomyosis

TypeinterventionalSponsorMỹ Đức HospitalRan2024 to 2027Enrolled222ConditionsAdenomyosis, IVF, Frozen Embryo TransferArmsGnRHa+AI - AC, Artificial cycle
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sezcan MumusogluDepartment of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey.
Mehtap PolatAnatolia IVF and Women Health Centre, Ankara, Turkey.
Irem Yarali OzbekAnatolia IVF and Women Health Centre, Ankara, Turkey.
Gurkan BozdagDepartment of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey.
Evangelos G PapanikolaouNature IVF Unit, Thessaloniki, Greece.
Sandro C EstevesAndrofert, Andrology and Human Reproduction Clinic, Referral Center for Male Reproduction, Campinas, Brazil.
Peter HumaidanDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Hakan YaraliDepartment of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey.
Zübeyde Hanim Maternity Hospital · TRHacettepe University · TRAarhus University · DKSkive Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the worldwide increase in frozen embryo transfer, the search for the best protocol to prime endometrium continues. Well-designed trials comparing various frozen embryo transfer protocols in terms of live birth rates, maternal, obstetric and neonatal outcome are urgently required. Currently, low-quality evidence indicates that, natural cycle, either true natural cycle or modified natural cycle, is superior to hormone replacement treatment protocol. Regarding warmed blastocyst transfer and frozen embryo transfer timing, the evidence suggests the 6

Indexed as

Embryo ImplantationEndometriumPregnancy RateCryopreservationEmbryo TransferFemaleHumansPregnancyfrozen embryo transferhormone replacement treatment cycleindividualized approachmodified natural cyclenatural cycletrue natural cycle

Identifiers

PMID34305815
PMCPMC8299049
OpenAlexW3180857116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.