ReviewFrontiers in neurology2021
Structural and Functional Connectivity Substrates of Cognitive Impairment in Multiple Sclerosis.
Review in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Correlation of cognitive dysfunctions and diffusion tensor MRI measures in subjects with RRMS.Frontiers in aging neuroscience · 2025Pooled it
- Clinically Relevant Patterns of Co-Fluctuating Structure and Function in Multiple Sclerosis.European journal of neurology · 2025Article
- Cerebellar microstructural and functional connectivity changes in patients with neuromyelitis optica spectrum disorders and their correlation with cognitive function: a female-dominated multimodal MRI study.Frontiers in neurology · 2025Article
- Combinations of multimodal neuroimaging biomarkers and cognitive test scores to identify patients with cognitive impairment.Frontiers in aging neuroscience · 2025Article
- White Matter Magnetic Resonance Diffusion Measures in Multiple Sclerosis with Overactive Bladder.Brain sciences · 2024Article
- Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Microscopic fractional anisotropy outperforms multiple sclerosis lesion assessment and clinical outcome associations over standard fractional anisotropy tensor.Human brain mapping · 2024Article
- Advanced MRI Techniques: Diagnosis and Follow-Up of Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2024Review
- Brain structure and connectivity mediate the association between lifestyle and cognition: The Maastricht Study.Brain communications · 2024Article
- Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis.Translational psychiatry · 2023Review
- Microstructural changes precede depression in patients with relapsing-remitting Multiple Sclerosis.Communications medicine · 2023Article
- Differences in resting state functional connectivity relative to multiple sclerosis and impaired information processing speed.Frontiers in neurology · 2023Article
- Increased flexibility of brain dynamics in patients with multiple sclerosis.Brain communications · 2023Article
- Compensatory Mechanisms in Early Alzheimer's Disease and Clinical Setting: The Need for Novel Neuropsychological Strategies.Journal of Alzheimer's disease reports · 2023Review
- An investigation of the association between focal damage and global network properties in cognitively impaired and cognitively preserved patients with multiple sclerosis.Frontiers in neuroscience · 2023Article
- Applying multilayer analysis to morphological, structural, and functional brain networks to identify relevant dysfunction patterns.Network neuroscience (Cambridge, Mass.) · 2022Article
- Aberrant brain gray matter and functional networks topology in end stage renal disease patients undergoing maintenance hemodialysis with cognitive impairment.Frontiers in neuroscience · 2022Article
- Functional MRI and cognition in multiple sclerosis-Where are we now?Journal of neuroimaging : official journal of the American Society of NeuroimagingReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive impairment (CI) occurs in 43 to 70% of multiple sclerosis (MS) patients at both early and later disease stages. Cognitive domains typically involved in MS include attention, information processing speed, memory, and executive control. The growing use of advanced magnetic resonance imaging (MRI) techniques is furthering our understanding on the altered structural connectivity (SC) and functional connectivity (FC) substrates of CI in MS. Regarding SC, different diffusion tensor imaging (DTI) measures (e.g., fractional anisotropy, diffusivities) along tractography-derived white matter (WM) tracts showed relevance toward CI. Novel diffusion MRI techniques, including diffusion kurtosis imaging, diffusion spectrum imaging, high angular resolution diffusion imaging, and neurite orientation dispersion and density imaging, showed more pathological specificity compared to the traditional DTI but require longer scan time and mathematical complexities for their interpretation. As for FC, task-based functional MRI (fMRI) has been traditionally used in MS to brain mapping the neural activity during various cognitive tasks. Analysis methods of resting fMRI (seed-based, independent component analysis, graph analysis) have been applied to uncover the functional substrates of CI in MS by revealing adaptive or maladaptive mechanisms of functional reorganization. The relevance for CI in MS of SC-FC relationships, reflecting common pathogenic mechanisms in WM and gray matter, has been recently explored by novel MRI analysis methods. This review summarizes recent advances on MRI techniques of SC and FC and their potential to provide a deeper understanding of the pathological substrates of CI in MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.