Evidence map›Paper›PMID 34305639›Full record

ArticleFrontiers in physiology2021

Circadian Genes as Exploratory Biomarkers in DMD: Results From Both the

Rachele Rossi, Maria Sofia Falzarano, Hana Osman, Annarita Armaroli, Chiara Scotton, Paola Mantuano, Brigida Boccanegra, Ornella Cappellari, Elena Schwartz, Anton Yuryev and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 4 countries.

Rachele RossiUnit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Maria Sofia FalzaranoUnit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Hana OsmanUnit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Annarita ArmaroliUnit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Chiara ScottonUnit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Paola MantuanoSection of Pharmacology, Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Brigida BoccanegraSection of Pharmacology, Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Ornella CappellariSection of Pharmacology, Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Elena SchwartzAmi-Go-Science LLC, Rockville, MD, United States.
Anton YuryevElsevier, Rockville, MD, United States.
Eugenio MercuriPediatric Neurology Unit, Catholic University and Nemo Center, Policlinico Universitario Gemelli, Rome, Italy.
Enrico BertiniUnit of Neuromuscular and Neurodegenerative Disorders, Department of Neurosciences, IRCCS Bambino Gesu Children's Hospital, Rome, Italy.
Adele D'AmicoUnit of Neuromuscular and Neurodegenerative Disorders, Department of Neurosciences, IRCCS Bambino Gesu Children's Hospital, Rome, Italy.
Marina MoraNeuromuscular Diseases and Neuroimmunology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Camilla JohanssonSchool of Chemistry, Biotechnology and Health, Royal Institute of Technology, Stockholm, Sweden.
Cristina Al-Khalili SzigyartoSchool of Chemistry, Biotechnology and Health, Royal Institute of Technology, Stockholm, Sweden.
Annamaria De LucaSection of Pharmacology, Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Bari, Italy.
Alessandra FerliniUnit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
University of Ferrara · ITUniversity of Bari Aldo Moro · ITBambino Gesù Children's Hospital · ITCentro Clinico Nemo · ITFondazione IRCCS Istituto Neurologico Carlo Besta · ITKTH Royal Institute of Technology · SERELX Group (United States) · USScience for Life Laboratory · SEUniversity of Khartoum · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a rare genetic disease due to dystrophin gene mutations which cause progressive weakness and muscle wasting. Circadian rhythm coordinates biological processes with the 24-h cycle and it plays a key role in maintaining muscle functions, both in animal models and in humans. We explored expression profiles of circadian circuit master genes both in Duchenne muscular dystrophy skeletal muscle and in its animal model, the mdx mouse. We designed a customized, mouse-specific Fluidic-Card-TaqMan-based assay (Fluid-CIRC) containing thirty-two genes related to circadian rhythm and muscle regeneration and analyzed gastrocnemius and tibialis anterior muscles from both unexercised and exercised

Indexed as

biomarkercircadian rhythmDuchenne muscular dystrophy (DMD)mdx miceRNA analysisskeletal muscle

Identifiers

PMID34305639
PMCPMC8300012
OpenAlexW3181306686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.