ReviewFrontiers in pharmacology2021
Drug Shortage: Causes, Impact, and Mitigation Strategies.
Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
129 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of COVID-19 Pandemic on Adherence to Chronic Therapies: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Manufacturer-Perceived Development and Market-Entry Risks Associated with Discontinuation and Non-launch of Generic Medicines in Japan: A Cross-Sectional Survey of Marketing Authorization Holders.Pharmaceutical medicine · 2026Article
- Contamination Rates and Economic Evaluation of Reusing Medicated, Preservative-Free, Single-Use Eye Drops.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Antibiotic Shortages: Pharmacists' Experiences, Perspectives, and Perceived Clinical Impacts.Antibiotics (Basel, Switzerland) · 2026Article
- From Product-Quality Complaints to Patient-Safety Triage: A Structured Narrative Review and Proposed PRCS-TRACE Framework.Healthcare (Basel, Switzerland) · 2026Review
- Stakeholder Perceptions on Innovative Private Pharmacy Distribution Channels and Implications for Medicine Quality in Zambia: A Qualitative Study.Global health, science and practice · 2026Article
- HopeFOL, or FOL of problems? Leucovorin for autistic symptoms.The oncologist · 2026Review
- Combining the optimization of the CT examination process with a vial sharing strategy for contrast agents: an economical and practical method for hospitals.BMC health services research · 2026Article
- A nationwide register study on medicines exiting the reimbursement system in 2010-2022.BMC health services research · 2026Article
- Structural drivers of drug shortages and market withdrawal: a longitudinal analysis of the Romanian pharmaceutical market.BMC health services research · 2026Article
- Drug price trends, regional disparities, and supply shortages under China's National Volume-Based Procurement: a nationwide analysis (2018-2024).BMC health services research · 2026Article
- Article
- Pharmaceutical import landscape in Ethiopia: a cross-sectional study of importers' perspectives on business and regulatory challenges.Tropical medicine and health · 2026Article
- Structural Patterns of Antibiotic Shortages: A Cross-National Analysis of Systemic Antibacterials.Antibiotics (Basel, Switzerland) · 2026Article
- Drug supply chain disruptions and outpatient medication shortages in the Veterans Health Administration, 2017-2020.Exploratory research in clinical and social pharmacy · 2026Article
- Supply Chain Events and Risk of Drug Shortage in Canada.JAMA network open · 2026Article
- Socioeconomic Determinants of Access to Medicines Among Romanian Patients with Chronic Diseases: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Burden and Impact of Drug Shortages in a Saudi Tertiary Hospital: A Single-Center Cross-Sectional Survey.Healthcare (Basel, Switzerland) · 2026Article
- Pharmacy student's awareness, perceptions, and supportive environment as determinants of their intent to pursue postgraduate education in pharmaceutical marketing: a cross-sectional study.BMC medical education · 2026Article
- Integrating Drug Repurposing into EU Health Crisis Preparedness: The Strategic Role of Health Emergency Preparedness and Response Authority (HERA).Pharmacy (Basel, Switzerland) · 2026Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug shortage is a global issue affecting low, middle, and high-income countries. Many countries have developed various strategies to overcome the problem, while the problem is accelerating, affecting the whole world. All types of drugs, such as essential life-saving drugs, oncology medicines, antimicrobial drugs, analgesics, opioids, cardiovascular drugs, radiopharmaceutical, and parenteral products, are liable to the shortage. Among all pharmaceutical dosage forms, sterile injectable products have a higher risk of shortage than other forms. The causes of shortage are multifactorial, including supply issues, demand issues, and regulatory issues. Supply issues consist of manufacturing problems, unavailability of raw materials, logistic problems, and business problems. In contrast, demand issues include just-in-time inventory, higher demand for a product, seasonal demand, and unpredictable demand. For regulatory issues, one important factor is the lack of a unified definition of drug shortage. Drug shortage affects all stakeholders from economic, clinical, and humanistic aspects. WHO established global mitigation strategies from four levels to overcome drug shortages globally. It includes a workaround to tackle the current shortage, operational improvements to reduce the shortage risk and achieve early warning, changes in governmental policies, and education and training of all health professionals about managing shortages.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.