Evidence map›Paper›PMID 34305452›Full record

Observational studyMediators of inflammation2021

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease.

Susanne Schulz, Martin Zielske, Sascha Schneider, Britt Hofmann, Hans-Günter Schaller, Axel Schlitt, Stefan Reichert

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Mediators of inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01045070 (Periodontitis and Its Microbiological Agents as Prognostic Factors in Patients With Coronary Heart Disease), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01045070 completednot on this map

Periodontitis and Its Microbiological Agents as Prognostic Factors in Patients With Coronary Heart Disease

TypeobservationalSponsorMartin-Luther-Universität Halle-WittenbergRan2009 to 2012Enrolled960ConditionsPeriodontitis, Coronary Heart Disease
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Susanne SchulzDepartment of Operative Dentistry and Periodontology, Martin Luther University of Halle-Wittenberg, Germany.ORCID https://orcid.org/0000-0003-4541-666X
Martin ZielskeDepartment of Operative Dentistry and Periodontology, Martin Luther University of Halle-Wittenberg, Germany.
Sascha SchneiderDepartment of Operative Dentistry and Periodontology, Martin Luther University of Halle-Wittenberg, Germany.
Britt HofmannDepartment of Cardiac Surgery, Mid-German Heart Centre of the University Hospital Halle (Saale), Martin Luther University of Halle-Wittenberg, Germany.ORCID https://orcid.org/0000-0002-2379-9623
Hans-Günter SchallerDepartment of Operative Dentistry and Periodontology, Martin Luther University of Halle-Wittenberg, Germany.
Axel SchlittDepartment of Internal Medicine III, Heart Centre of the University Clinics Halle (Saale), Martin Luther University of Halle-Wittenberg, Germany.ORCID https://orcid.org/0000-0002-3956-3519
Stefan ReichertDepartment of Operative Dentistry and Periodontology, Martin Luther University of Halle-Wittenberg, Germany.ORCID https://orcid.org/0000-0001-5291-5067
Martin Luther University Halle-Wittenberg · DEDeutsches Herzzentrum München · DEParacelsus-Harz-Klinik Bad Suderode · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe biological link between severe periodontitis and cardiovascular disease is well established. Both complex inflammatory diseases are influenced by genetic background. Therefore, the impact of genetic variations of receptors of the innate immune system-(Toll-like receptors (TLRs)) TLR2, TLR4, cluster of differentiation 14 (CD14), and the transcription factor nuclear factor- MATERIALS AND

methodsIn this study (ClinicalTrials.gov identifier: NCT01045070), 1002 cardiovascular (CV) patients were included. In a 3-year follow-up period, new vascular events were assessed. SNPs in CD14 (rs2569190), NF-

resultsAll investigated genetic variants were not associated with preexisting CV events or severe periodontitis in CV patients. In Kaplan-Meier survival analyses, the CT genotype of CD14 single-nucleotide polymorphism (SNP) rs2569190 was shown to be an independent predictor for combined CV endpoint (log rank:

conclusionsSNPs in CD14, NF-

Indexed as

Cardiovascular DiseasesLipopolysaccharide ReceptorsPeriodontitisGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideToll-Like ReceptorsLipopolysaccharide ReceptorsToll-Like Receptors

Identifiers

PMID34305452
PMCPMC8282382
OpenAlexW3182278516

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.