ReviewInfectious diseases in obstetrics and gynecology2021
Giant Condyloma Acuminata (Buschke-Lowenstein Tumor): Review of an Unusual Disease and Difficult to Manage.
Review in Infectious diseases in obstetrics and gynecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Surgical excision for giant condyloma acuminatum (Buschke-Löwenstein tumor): A case report.Case reports in women's health · 2026Article
- A Two-Decade Journey of Buschke-Löwenstein Tumor Without Malignant Transformation: Clinical Insights and Management.Cureus · 2026Article
- Article
- Rapidly Progressive Perianal Giant Condyloma in an Immunocompetent Adolescent: An Unusual Abuse-Associated Case.Clinical, cosmetic and investigational dermatology · 2026Article
- Unmasking the Giant Condyloma: A Case Report and Literature Review of Buschke-Löwenstein Tumor.Cureus · 2025Article
- Effective treatment of a giant condyloma with imiquimod and HPV vaccination.Gynecologic oncology reports · 2025Article
- Buschke-Löwenstein Tumor: An Unusual Therapeutic Approach.GE Portuguese journal of gastroenterology · 2025Article
- Buschke-Löwenstein Tumour: Surgical Management and Literature Review of an Unusual Disease.Cureus · 2025Article
- Recurrence rate of perianal and intra-anal genital warts treated with aminolevulinic acid photodynamic therapy: a meta-analysis.Frontiers in reproductive health · 2025Review
- Article
- Clinicopathological Findings and Comprehensive Review of Buschke-Lowenstein Tumors Based on a Case Study.Journal of personalized medicine · 2024Article
- Surgical treatment of perineal giant condylomata acuminata (Buschke Lowenstein tumor): Case series from a developing country.International journal of surgery case reports · 2024Article
- Penile Buschke-Lowenstein tumor in HCV patient.Urology case reports · 2024Article
- A rare presentation of a rare entity: giant condyloma (Buschke-Löwenstein) tumor.Journal of surgical case reports · 2024Article
- Sex Steroid Modulators and the Development of Buschke-Lowenstein Tumor: A Case Report of an Immunocompetent Patient.Cureus · 2023Article
- Giant condyloma acuminatum (Buschke-Lowenstein tumour) of the vagina during pregnancy.BMJ case reports · 2023Article
- Surgical Management of Perianal Giant Condyloma Acuminatum of Buschke and Löwenstein: Case Presentation.Life (Basel, Switzerland) · 2023Article
- CT imaging of condyloma acuminata.Radiology case reports · 2023Article
- Vulvar condyloma of Buschke and Löwenstein: an unusual tumour in developed countries.BMJ case reports · 2022Article
- The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giant condyloma acuminatum (GCA) or Buschke-Loewenstein tumor is a rare disease, with an estimated prevalence of 0.1%. It was initially described in 1896 by Buschke and later in 1925 by Buschke and Loewenstein. Classic condyloma acuminata (CCA) and squamous cell carcinoma (SCC) were initially described as different entities. These three entities are currently considered to correspond to the same spectrum of different but not exclusive malignant transformations, associated with multiple risk factors such infection by human papilloma virus (HPV), immunodeficiencies, poor hygiene, multiple sexual partners, and chronic genital infections. HPV subtypes 6 and 11 are associated with 90% of GCA. It presents as a cauliflower-like tumor in the genital region with bad odor, bleeding, and local infection, differential diagnosis with multiple conditions should be considered, and sexually transmitted diseases should always be investigated. GCA has a higher rate of malignant transformation than CCA and tends to infiltrate adjacent soft tissues. The therapeutic approach is controversial but is considered that the resection with free edges is the gold standard and can be combined with adjuncts. The recurrence rate is high. Overall mortality is 21% and is associated with morbidity caused by recurrences. Imiquimod cream 5% has recently shown good results as monotherapy and in combination with ablative and surgical treatments. The quality of life is diminished in patients with this condition. In this review, we address the different aspects of this rare entity including the therapeutic approach.
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