Evidence map›Paper›PMID 34305200›Full record

ArticleOptics and lasers in engineering2021

Two-photon polymerization nanofabrication of ultracompact light scattering spectroscopic probe for detection of pre-cancer in pancreatic cyst.

Conor J Sheil, Umar Khan, Yuri N Zakharov, Mark F Coughlan, Douglas K Pleskow, Mandeep S Sawhney, Tyler M Berzin, Jonah M Cohen, Maria Glyavina, Lei Zhang and 3 more

Open access · greenAbstract read
In one paragraph

Article in Optics and lasers in engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Conor J Sheil *Center for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Umar Khan *Center for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Yuri N ZakharovCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Mark F CoughlanCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Douglas K PleskowCenter for Advanced Endoscopy, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Mandeep S SawhneyCenter for Advanced Endoscopy, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Tyler M BerzinCenter for Advanced Endoscopy, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Jonah M CohenCenter for Advanced Endoscopy, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Maria GlyavinaCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Lei ZhangCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Irving ItzkanCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Lev T PerelmanCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Le QiuCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University.
Hadassah Medical Center · ILHarvard University · US

Funding

In Vivo Optical Detection of Dysplasia in EsophagusR01EB003472 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PERELMAN, LEV T · 2005 to 2019
$6.1M
Endoscopic Fine-Needle Polarized Scanning Spectroscopy for Pancreatic Cystic Lesions DiagnosisR01EB025173 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Lev T Perelman · 2017 to 2026
$4.7M
Spectro-Holographic Instrument for Dynamic Sensing of Cancer ProgressionR01CA228029 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PERELMAN, LEV T · 2018 to 2023
$3.4M
Isolation and Assessment of Blood-Circulating Cancer Exosomes with LSS and SERS Lab on a Chip Optical Spectroscopic InstrumentR01CA218382 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PERELMAN, LEV T · 2018 to 2022
$3.3M
(PQ7) In Vivo Cellular Optical Imaging of Esophageal Tumors and MicroenvironmentR01CA205431 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PERELMAN, LEV T · 2016 to 2020
$2.6M
NCI NIH HHS R01 CA205431NCI NIH HHS R01 CA218382NCI NIH HHS R01 CA228029NIBIB NIH HHS R01 EB003472NIBIB NIH HHS R01 EB025173
6 · The paper itself

Abstract

Pancreatic cancer has one of the worst survival rates of all major cancers, with pancreatic cystic lesions accounting for one in three pancreatic surgeries. The current gold-standard for diagnosis of pancreatic cyst malignancy is based on the endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) procedure, which suffers from a low accuracy in detecting malignancy. Here we present the design and two-photon polymerization based fabrication of refractive and reflective non-contact probes, capable of rapid surveillance of the entire internal cyst surface-an advance over the contact probe we recently developed that allowed, for the first time, reliable evaluation of pancreatic cyst malignant potential

Indexed as

cancerlight scatteringnanofabricationprobetwo-photon polymerization

Identifiers

PMID34305200
PMCPMC8294208
OpenAlexW3137448060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.