ArticleMechanics research communications2021
Computational investigation of left ventricular hemodynamics following bioprosthetic aortic and mitral valve replacement.
Article in Mechanics research communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 64 citations in OpenAlex.
- ValveFit: An analysis-suitable B-spline-based surface fitting framework for patient-specific modeling of tricuspid valves.Computer methods in applied mechanics and engineering · 2026Article
- Mechano-electrical-fluid interaction left-ventricle model for numerical evaluation of aortic valve hemodynamics.Frontiers in bioengineering and biotechnology · 2025Article
- Multi-Modal in Vitro Experiments Mimicking the Flow Through a Mitral Heart Valve Phantom.Cardiovascular engineering and technology · 2024Article
- Current progress toward isogeometric modeling of the heart biophysics.Biophysics reviews · 2023Review
- Blood-Artery Interaction in Calcified Aortas and Abdominal Aortic Aneurysms.Extreme Mechanics Letters · 2022Article
- Variational coupling of non-matching discretizations across finitely deforming fluid-structure interfaces.International journal for numerical methods in fluids · 2022Article
- Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022Review
- Effects of membrane and flexural stiffnesses on aortic valve dynamics: identifying the mechanics of leaflet flutter in thinner biological tissues.Forces in mechanics · 2022Article
- Simulating the time evolving geometry, mechanical properties, and fibrous structure of bioprosthetic heart valve leaflets under cyclic loading.Journal of the mechanical behavior of biomedical materials · 2021Article
- Weakly imposed boundary conditions for shear-rate dependent non-Newtonian fluids: application to cardiovascular flows.Mathematical biosciences and engineering : MBE · 2021Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The left ventricle of the heart is a fundamental structure in the human cardiac system that pumps oxygenated blood into the systemic circulation. Several valvular conditions can cause the aortic and mitral valves associated with the left ventricle to become severely diseased and require replacement. However, the clinical outcomes of such operations, specifically the postoperative ventricular hemodynamics of replacing both valves, are not well understood. This work uses computational fluid-structure interaction (FSI) to develop an improved understanding of this effect by modeling a left ventricle with the aortic and mitral valves replaced with bioprostheses. We use a hybrid Arbitrary Lagrangian-Eulerian/immersogeometric framework to accommodate the analysis of cardiac hemodynamics and heart valve structural mechanics in a moving fluid domain. The motion of the endocardium is obtained from a cardiac biomechanics simulation and provided as an input to the proposed numerical framework. The results from the simulations in this work indicate that the replacement of the native mitral valve with a tri-radially symmetric bioprosthesis dramatically changes the ventricular hemodynamics. Most significantly, the vortical motion in the left ventricle is found to reverse direction after mitral valve replacement. This study demonstrates that the proposed computational FSI framework is capable of simulating complex multiphysics problems and can provide an in-depth understanding of the cardiac mechanics.
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