Evidence map›Paper›PMID 34305084›Full record

ArticleJournal of atherosclerosis and thrombosis2022

Association of Asymptomatic Low Ankle-Brachial Index with Long-Term Clinical Outcomes in Patients after Acute Myocardial Infarction.

Soichiro Ban, Kenichi Sakakura, Hiroyuki Jinnouchi, Yousuke Taniguchi, Takunori Tsukui, Yusuke Watanabe, Kei Yamamoto, Masaru Seguchi, Hiroshi Wada, Hideo Fujita

Open access · diamondAbstract read
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Soichiro BanDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Kenichi SakakuraDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Hiroyuki JinnouchiDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Yousuke TaniguchiDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Takunori TsukuiDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Yusuke WatanabeDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Kei YamamotoDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Masaru SeguchiDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Hiroshi WadaDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Hideo FujitaDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Jichi Medical University Saitama Medical Center · JPJichi Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPeripheral arterial disease (PAD) is the well-known risk factor for cardiovascular events. Although low ankle-brachial index (ABI) is recognized as a risk factor in general population, low ABI without any symptoms of PAD has not been established as a prognostic marker in patients with acute myocardial infarction (AMI) yet. The purpose of this retrospective study was to examine whether asymptomatic low ABI was associated with long-term clinical outcomes in AMI patients without treatment history of PAD.

methodsWe included 850 AMI patients without a history of PAD and divided them into the preserved ABI (ABI ≥ 0.9) group (n=760) and the reduced ABI (ABI <0.9) group (n=90) on the basis of the ABI measurement during the hospitalization. The primary endpoint was the major adverse cardiovascular events (MACE) defined as the composite of all-cause death, non-fatal myocardial infarction, and hospitalization for heart failure.

resultsDuring the median follow-up duration of 497 days (Q1: 219 days to Q3: 929 days), a total of 152 MACE were observed. The Kaplan-Meier curves showed that MACE were more frequently observed in the reduced ABI group than in the preserved ABI group (p<0.001). The multivariate COX hazard analysis revealed that reduced ABI was significantly associated with MACE (hazard ratio 2.046, 95% confidence interval 1.344-3.144, p=0.001) after controlling confounding factors.

conclusionsReduced ABI was significantly associated with long-term adverse events in AMI patients without a history of PAD. Our results suggest the usefulness of ABI as a prognostic marker in AMI patients irrespective of symptomatic PAD.

Indexed as

Myocardial InfarctionPeripheral Arterial DiseaseAnkle Brachial IndexHumansPredictive Value of TestsPrognosisRetrospective StudiesRisk FactorsAcute myocardial infarctionAnkle–brachial indexPeripheral artery disease

Identifiers

PMID34305084
PMCPMC9252618
OpenAlexW3185768281

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.