Evidence map›Paper›PMID 34304585›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Degradation of Premature-miR-181b by the Translin/Trax RNase Increases Vascular Smooth Muscle Cell Stiffness.

Eric Tuday, Mitsunori Nakano, Kei Akiyoshi, Xiuping Fu, Aparna P Shah, Atsushi Yamaguchi, Charles Steenbergen, Lakshmi Santhanam, Steven S An, Dan Berkowitz and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Adenosine AJournal of the American Heart Association · 2023
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Eric TudayFrom the Geriatric Research Education and Clinical Center (GRECC), Veterans Affairs, Salt Lake City, UT (E.T.).
Mitsunori NakanoDepartment of Anesthesiology and Critical Care Medicine (M.N., L.S., S.D.), Johns Hopkins School of Medicine, Baltimore, MD.
Kei Akiyoshi
Xiuping FuSolomon H. Snyder Department of Neuroscience (X.F., A.P.S., J.M.B.), Johns Hopkins School of Medicine, Baltimore, MD.
Aparna P ShahSolomon H. Snyder Department of Neuroscience (X.F., A.P.S., J.M.B.), Johns Hopkins School of Medicine, Baltimore, MD.
Atsushi YamaguchiDepartment of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Japan (A.Y.).
Charles SteenbergenDepartment of Pathology (C.S., S.D.), Johns Hopkins School of Medicine, Baltimore, MD.
Lakshmi SanthanamDepartment of Anesthesiology and Critical Care Medicine (M.N., L.S., S.D.), Johns Hopkins School of Medicine, Baltimore, MD.
Steven S AnDepartment of Pharmacology, Rutgers-Robert Wood Johnson Medical School, The State University of New Jersey, Piscataway (S.S.A.).
Dan BerkowitzDepartment of Anesthesiology and Perioperative Medicine, The University of Alabama at Birmingham, AL (D.B.).
Jay M BarabanSolomon H. Snyder Department of Neuroscience (X.F., A.P.S., J.M.B.), Johns Hopkins School of Medicine, Baltimore, MD.
Samarjit DasDepartment of Anesthesiology and Critical Care Medicine (M.N., L.S., S.D.), Johns Hopkins School of Medicine, Baltimore, MD.
Johns Hopkins University · USJichi Medical University · JPRutgers, The State University of New Jersey · USUniversity of Alabama at Birmingham · USUniversity of Utah · US

Funding

Project 4 - OGR1- and TSPO- dependent mechanisms mediated by benzodiazepines affecting ASM contractionP01HL114471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PANETTIERI, REYNOLD ALEXANDER · 2013 to 2023
$23.9M
PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
Sex differences in the impact of frailty on vaccine-induced immune responses in community-dwelling older adultsU54AG062333 · NIA · JOHNS HOPKINS UNIVERSITY · PI MORGAN, ROSEMARY · 2018 to 2022
$8.9M
NEUROHUMORAL CONTROL OF INTERNAL ANAL SPINCHTERR01DK035385 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI RATTAN, SATISH · 1986 to 2020
$7.8M
Exosome-based Non-traditional Technologies Towards Multi-Parametric andIntegrated Approaches for SARS-CoV-2U18TR003780 · NCATS · JOHNS HOPKINS UNIVERSITY · PI DAS, SAMARJIT · 2021 to 2022
$2.0M
The Role of MicroRNA 181b in the Development of Vascular Stiffness with AgeK08AG070281 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI TUDAY, ERIC · 2021 to 2025
$859k
NCATS NIH HHS U18 TR003780NHLBI NIH HHS P01 HL114471NHLBI NIH HHS T32 HL007227NIA NIH HHS K08 AG070281NIA NIH HHS U54 AG062333NIDDK NIH HHS R01 DK035385
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsAortaArginine VasopressinDNA-Binding ProteinsMiceMicroRNAsMuscle, Smooth, VascularMyocytes, Smooth MuscleVascular StiffnessArginine VasopressinDNA-Binding ProteinsMicroRNAsmirn181 microRNA, mouseTSN protein, humanaortacardiovascular diseasesmicroRNA degradationrisk factorsvascular smooth musclevasopressin

Identifiers

PMID34304585
PMCPMC8363557
OpenAlexW3183497700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.