Evidence map›Paper›PMID 34304582›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension.

Rhéure Alves-Lopes, Augusto C Montezano, Karla B Neves, Adam Harvey, Francisco J Rios, Dominik S Skiba, Lauren B Arendse, Tomasz J Guzik, Delyth Graham, Marko Poglitsch and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Phytochemical Investigation ofMolecules (Basel, Switzerland) · 2024
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Exploring the Impact of ACE Inhibition in Immunity and Disease.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Rhéure Alves-LopesInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (R.A.-L., A.C.M., K.B.N., A.H., F.J.R., D.S.S., T.J.G., D.G., R.M.T.).
Augusto C MontezanoInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (R.A.-L., A.C.M., K.B.N., A.H., F.J.R., D.S.S., T.J.G., D.G., R.M.T.).
Karla B NevesInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (R.A.-L., A.C.M., K.B.N., A.H., F.J.R., D.S.S., T.J.G., D.G., R.M.T.).
Adam HarveyInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (R.A.-L., A.C.M., K.B.N., A.H., F.J.R., D.S.S., T.J.G., D.G., R.M.T.).
Francisco J RiosInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (R.A.-L., A.C.M., K.B.N., A.H., F.J.R., D.S.S., T.J.G., D.G., R.M.T.).
Dominik S SkibaInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (R.A.-L., A.C.M., K.B.N., A.H., F.J.R., D.S.S., T.J.G., D.G., R.M.T.).
Lauren B ArendseInstitute of Infectious Disease and Molecular Medicine and Division of Medical Biochemistry, University of Cape Town, South Africa (L.B.A., E.S.).
Tomasz J GuzikInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (R.A.-L., A.C.M., K.B.N., A.H., F.J.R., D.S.S., T.J.G., D.G., R.M.T.).
Delyth GrahamInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (R.A.-L., A.C.M., K.B.N., A.H., F.J.R., D.S.S., T.J.G., D.G., R.M.T.).
Marko PoglitschAttoquant Diagnostics GmbH, Vienna, Austria (M.P).
Edward SturrockInstitute of Infectious Disease and Molecular Medicine and Division of Medical Biochemistry, University of Cape Town, South Africa (L.B.A., E.S.).
Rhian M TouyzInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (R.A.-L., A.C.M., K.B.N., A.H., F.J.R., D.S.S., T.J.G., D.G., R.M.T.).
British Heart Foundation · GBCardiovascular Institute of the South · USWellcome Centre for Infectious Diseases Research in Africa · ZALudwig Boltzmann Institute Applied Diagnostics · AT

Funding

British Heart Foundation 18/6/34217British Heart Foundation CH/12/29762British Heart Foundation CH/12/4/29762British Heart Foundation RE/13/5/30177Medical Research Council MC-PC-15076Medical Research Council MC_PC_15076
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AminobutyratesAngiotensin-Converting Enzyme InhibitorsAnimalsAntihypertensive AgentsBiphenyl CompoundsBlood PressureBody WeightHypertensionLisinoprilLiverMiceMice, TransgenicNeprilysinPyridinesReninThiazepinesAminobutyratesAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsBiphenyl CompoundsLisinoprilNeprilysinomapatrilatPyridinesReninsacubitrilThiazepinesblood pressureneprilysinomapatrilatpermeabilityvasodilatation

Identifiers

PMID34304582
PMCPMC8357049
OpenAlexW3183153307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.