Evidence map›Paper›PMID 34304389›Full record

ReviewGeroScience2021

University of Alabama at Birmingham Nathan Shock Center: comparative energetics of aging.

Steven N Austad, Thomas W Buford, David B Allison, Scott W Ballinger, Andrew W Brown, Christy S Carter, Victor M Darley-Usmar, John L Hartman, Timothy R Nagy, Daniel L Smith and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Steven N AustadDepartment of Biology, University of Alabama At Birmingham, Birmingham, AL, USA. austad@uab.edu.ORCID http://orcid.org/0000-0003-4798-8442
Thomas W BufordDepartment of Medicine, University of Alabama At Birmingham, Birmingham, AL, USA.
David B AllisonDepartment of Epidemiology and Biostatistics, Indiana University-Bloomington, Bloomington, IN, USA.
Scott W BallingerDepartment of Pathology, University of Alabama At Birmingham, Birmingham, AL, USA.
Andrew W BrownDepartment of Applied Health Sciences, Indiana University-Bloomington, Bloomington, USA.
Christy S CarterDepartment of Medicine, University of Alabama At Birmingham, Birmingham, AL, USA.
Victor M Darley-UsmarDepartment of Pathology, University of Alabama At Birmingham, Birmingham, AL, USA.
John L HartmanDepartment of Genetics, University of Alabama At Birmingham, Birmingham, AL, USA.
Timothy R NagyDepartment of Nutrition Sciences, University of Alabama At Birmingham, Birmingham, AL, USA.
Daniel L SmithDepartment of Nutrition Sciences, University of Alabama At Birmingham, Birmingham, AL, USA.
Liou SunDepartment of Biology, University of Alabama At Birmingham, Birmingham, AL, USA.
Jianhua ZhangDepartment of Pathology, University of Alabama At Birmingham, Birmingham, AL, USA.

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Sex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVID B ALLISON · 2015 to 2026
$11.3M
Longevity assurance interventions, metabolic health and Alzheimer's DiseaseR01AG057734 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SUN, LIOU · 2018 to 2022
$2.5M
NIA NIH HHS P30 AG050886NIA NIH HHS R01 AG057734NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

The UAB Nathan Shock Center focuses on comparative energetics and aging. Energetics, as defined for this purpose, encompasses the causes, mechanisms, and consequences of the acquisition, storage, and use of metabolizable energy. Comparative energetics is the study of metabolic processes at multiple scales and across multiple species as it relates to health and aging. The link between energetics and aging is increasingly understood in terms of dysregulated mitochondrial function, altered metabolic signaling, and aberrant nutrient responsiveness with increasing age. The center offers world-class expertise in comprehensive, integrated energetic assessment and analysis from the level of the organelle to the organism and across species from the size of worms to rats as well as state-of-the-art data analytics. The range of services offered by our three research cores, (1) The Organismal Energetics Core, (2) Mitometabolism Core, and (3) Data Analytics Core, is described herein.

Indexed as

AgingMitochondriaAnimalsRatsSignal TransductionAgingAnalyticsBioenergeticsComparative biologyEnergeticsMetabolismMitochondria

Identifiers

PMID34304389
PMCPMC8599596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.