Evidence map›Paper›PMID 34304133›Full record

ArticleBioorganic & medicinal chemistry2021

Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.

Suresh K Bowroju, Narsimha R Penthala, Naga Rajiv Lakkaniga, Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Robert J Shmookler Reis, Peter A Crooks

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Protein homeostasis in the aged and diseased heart.The journal of cardiovascular aging · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Suresh K BowrojuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
Narsimha R PenthalaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
Naga Rajiv LakkanigaDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
Meenakshisundaram BalasubramaniamDepartment of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
Srinivas AyyadevaraDepartment of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
Robert J Shmookler ReisDepartment of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States; Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, United States; BioInformatics Program, University of Arkansas for Medical Sciences and University of Arkansas at Little Rock, Little Rock, AR 72205, United States.
Peter A CrooksDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States. Electronic address: pacrooks@uams.edu.
University of Arkansas for Medical Sciences · USScripps Research Institute · USUniversity of Arkansas at Little Rock · US

Funding

THE APOE-APP AXIS IN ALZHEIMER PATHOGENESISP01AG012411 · NIA · UNIV OF ARKANSAS FOR MED SCIS · PI BARGER, STEVEN W · 1995 to 2020
$25.0M
BLR&D Research Career Scientist AwardIK6BX004851 · VA · CENTRAL ARKANSAS VETERANS HLTHCARE SYS · PI Robert Joseph Shmookler Reis · 2020 to 2026
–
BLRD VA I01 BX001655BLRD VA IK6 BX004851NIA NIH HHS P01 AG012411
6 · The paper itself

Abstract

A series of novel 2-hydroxybenzylamine-deoxyvasicinone hybrid analogs (8a-8n) have been synthesized and evaluated as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and as inhibitors of amyloid peptide (Aβ

Indexed as

AcetylcholinesteraseAlkaloidsAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBenzylaminesButyrylcholinesteraseCholinesterase InhibitorsDose-Response Relationship, DrugElectrophorusHorsesHumansMolecular StructureNeuroprotective AgentsPeptide FragmentsProtein AggregatesAcetylcholinesteraseAlkaloidsAmyloid beta-Peptidesamyloid beta-protein (1-42)benzylamineBenzylaminesButyrylcholinesteraseCholinesterase InhibitorsNeuroprotective AgentsPeptide FragmentsProtein Aggregatesvasicinone2-HydroxybenzylamineAcetylcholinesterase inhibitorsAlzheimer’s diseaseAβ(1-42) peptide AggregationDeoxyvasicinone

Identifiers

PMID34304133
PMCPMC8405574
OpenAlexW3182003458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.