Evidence map›Paper›PMID 34304004›Full record

ArticleOral oncology2021

Biologic and behavioral associations of estrogen receptor alpha positivity in head and neck squamous cell carcinoma.

Virginia Drake, Elaine Bigelow, Carole Fakhry, Melina Windon, Lisa M Rooper, Patrick Ha, Brett Miles, Christine Gourin, Rajarsi Mandal, Wojciech Mydlarz and 7 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Virginia DrakeDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States.
Elaine BigelowDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States.
Carole FakhryDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States.
Melina WindonDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States.
Lisa M RooperDepartment of Pathology, Johns Hopkins University, Baltimore, MD, United States.
Patrick HaDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, United States.
Brett MilesDepartment of Otolaryngology-Head and Neck Surgery, Mount Sinai Health System, New York City, NY, United States.
Christine GourinDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States.
Rajarsi MandalDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States.
Wojciech MydlarzDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States.
Nyall LondonDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States.
Peter S VoslerDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States.
Siddhartha YavvariDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Tanya TroyDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Tim WaterboerInfections and Cancer Epidemiology, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
David W EiseleDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States.
Gypsyamber D'SouzaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: gdsouza2@jhu.edu.
Johns Hopkins University · USGerman Cancer Research Center · DEMount Sinai Health System · USUniversity of California, San Francisco · US

Funding

TUMOR SUPPRESOR GENE PROMOTER HYPERMETHYLATION FOR DETECTION OF HEAD AND NECKP50DE019032 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI SIDRANSKY, DAVID · 2007 to 2016
$27.1M
NIDCR NIH HHS P50 DE019032
6 · The paper itself

Abstract

objectivesTumor HPV status is an established independent prognostic marker for oropharynx cancer (OPC). Recent studies have reported that tumor estrogen receptor alpha (ERα) positivity is also associated with prognosis independent of HPV. Little is known about the biologic and behavioral predictors of ERα positivity in head and neck squamous cell cancer (HNSCC). We therefore explored this in a multicenter prospective cohort study. MATERIALS AND

methodsParticipants with HNSCC completed a survey and provided a blood sample. Tumor samples were tested for ERα using immunohistochemistry. ERα positivity was defined as ≥1%, standardized by the American Society of Clinical Oncology/College of American Pathologists in breast cancer. Characteristics were compared with χ

resultsOf 318 patients with HNSCC, one third had ERα positive tumors (36.2%, n = 115). Odds of ERα expression were significantly increased in those with HPV-positive tumors (OR = 27.5, 95% confidence interval[CI] 12.1-62), smaller tumors (≤T2, OR = 3.6, 95% CI 1.9-7.1), male sex (OR = 2.0, 95% CI 1.1-3.6), overweight/obesity (BMI ≥ 25, OR = 1.9, 95% CI 1.1-3.3), and those married/living with a partner (OR = 1.7, 95% CI 1.0-3.0). In a multivariate model, HPV-positivity (aOR = 27.5, 95% CI 11.4-66) and small tumor size (≤T2, aOR = 2.2, 95% CI 1.0-4.8) remained independently associated with ERα status. When restricted to OPC (n = 180), tumor HPV status (aOR = 17.1, 95% CI 2.1-137) and small tumor size (≤T2, aOR = 4.0 95% CI 1.4-11.3) remained independently associated with ERα expression.

conclusionTumor HPV status and small tumor size are independently associated with ERα expression in HNSCC.

Indexed as

Head and Neck NeoplasmsOropharyngeal NeoplasmsPapillomavirus InfectionsSquamous Cell Carcinoma of Head and NeckEstrogen Receptor alphaFemaleHumansMalePrognosisProspective StudiesEstrogen Receptor alphaEstrogen receptor alphaHead and neck neoplasmsOropharyngeal neoplasmsPapillomaviridaeTumor biomarkers

Identifiers

PMID34304004
PMCPMC8448948
OpenAlexW3186628851

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.