Evidence map›Paper›PMID 34303892›Full record

ArticleMedical image analysis2021

Weakly unsupervised conditional generative adversarial network for image-based prognostic prediction for COVID-19 patients based on chest CT.

Tomoki Uemura, Janne J Näppi, Chinatsu Watari, Toru Hironaka, Tohru Kamiya, Hiroyuki Yoshida

Abstract read
In one paragraph

Article in Medical image analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Lesion segmentation in lung CT scans using unsupervised adversarial learning.Medical & biological engineering & computing · 2022
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tomoki Uemura3D Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Mechanical and Control Engineering, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan.
Janne J Näppi3D Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Chinatsu Watari3D Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Toru Hironaka3D Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Tohru KamiyaDepartment of Mechanical and Control Engineering, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan.
Hiroyuki Yoshida3D Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: yoshida.hiro@mgh.harvard.edu.

Funding

Spectral precision imaging for early diagnosis of colorectal lesions with CT colonographyR01CA212382 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI YOSHIDA, HIROYUKI · 2018 to 2022
$1.5M
Deep radiomic decision support system for colorectal cancerR01EB023942 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI YOSHIDA, HIROYUKI · 2017 to 2019
$1.3M
Deep-radiomics-learning for mass detection in CT colonographyR21EB022747 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI NAPPI, JANNE JOHANNES · 2016 to 2017
$470k
Deep radiomic colon cleansing for laxative-free CT colonographyR21EB024025 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI NAPPI, JANNE JOHANNES · 2017 to 2018
$470k
NCI NIH HHS R01 CA212382NIBIB NIH HHS R01 EB023942NIBIB NIH HHS R21 EB022747NIBIB NIH HHS R21 EB024025
6 · The paper itself

Abstract

Because of the rapid spread and wide range of the clinical manifestations of the coronavirus disease 2019 (COVID-19), fast and accurate estimation of the disease progression and mortality is vital for the management of the patients. Currently available image-based prognostic predictors for patients with COVID-19 are largely limited to semi-automated schemes with manually designed features and supervised learning, and the survival analysis is largely limited to logistic regression. We developed a weakly unsupervised conditional generative adversarial network, called pix2surv, which can be trained to estimate the time-to-event information for survival analysis directly from the chest computed tomography (CT) images of a patient. We show that the performance of pix2surv based on CT images significantly outperforms those of existing laboratory tests and image-based visual and quantitative predictors in estimating the disease progression and mortality of COVID-19 patients. Thus, pix2surv is a promising approach for performing image-based prognostic predictions.

Indexed as

COVID-19HumansPrognosisSARS-CoV-2ThoraxTomography, X-Ray ComputedComputed tomographyCOVID-19Survival analysisUnsupervised deep learning

Identifiers

PMID34303892
PMCPMC8272947

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.