Evidence map›Paper›PMID 34303772›Full record

ArticleDiabetes research and clinical practice2021

Maternal height, gestational diabetes mellitus and pregnancy complications.

Anne H Y Chu, Wen Lun Yuan, See Ling Loy, Shu E Soh, Jonathan Y Bernard, Mya-Thway Tint, Sarah S T Ho-Lim, Huecin Goh, Adaikalavan Ramasamy, Mukkesh Kumar and 13 more

Open access · greenAbstract read
In one paragraph

Article in Diabetes research and clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. The Effect of SerumComputational and mathematical methods in medicine · 2022
    Pooled it
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  8. Maternal Height Is an Independent Risk of Adverse Outcomes in Women with Gestational Diabetes Mellitus.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 4 countries.

Anne H Y ChuSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
Wen Lun YuanDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
See Ling LoyDepartment of Reproductive Medicine, KK Women's and Children Hospital, Singapore; Duke-NUS Medical School, Singapore.
Shu E SohDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jonathan Y BernardSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Centre for Research in Epidemiology and StatisticS (CRESS), Université de Paris, Inserm, INRAE, Paris, France.
Mya-Thway TintSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Sarah S T Ho-LimDepartment of Nursing, National University Hospital, Singapore.
Huecin GohDepartment of Nursing, National University Hospital, Singapore.
Adaikalavan RamasamySingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
Mukkesh KumarSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
Claire GohSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
Li Ting AngSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
Lynette Pei-Chi ShekSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Yap Seng ChongSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Kok Hian TanDuke-NUS Medical School, Singapore; Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore.
Lin Lin SuDepartment of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
Arijit BiswasDepartment of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
Fabian YapLee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
Yung Seng LeeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Claudia ChiDepartment of Obstetrics and Gynaecology, National University Hospital, Singapore.
Keith M GodfreyMRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, UK.
Johan Gunnar ErikssonSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of General Practice and Primary Health Care, University of Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland.
Shiao-Yng ChanSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: obgchan@nus.edu.sg.
Singapore Institute for Clinical Sciences · SGNational University of Singapore · SGAgency for Science, Technology and Research · SGNational University Hospital · SGKK Women's and Children's Hospital · SGInserm · FRNanyang Technological University · SGUniversity Hospital Southampton NHS Foundation Trust · GB

Funding

Interdisciplinary Research Network on Early Adversity & Later Life ReversibilityU24AG047867 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GODFREY, KEITH, MCEWEN, BRUCE S. · 2014 to 2018
$954k
British Heart Foundation RG/15/17/31749Medical Research Council MC_PC_21000Medical Research Council MC_PC_21001Medical Research Council MC_PC_21003Medical Research Council MC_UU_12011/4NIA NIH HHS U24 AG047867
6 · The paper itself

Abstract

aimsTo explore the glucose-overload hypothesis of artefactual gestational diabetes (GDM) diagnosis in shorter women during oral glucose tolerance testing (OGTT), by investigating associations between height and maternal glycemia; and GDM and pregnancy complications in height-groups.

methodsWomen from GUSTO (n = 1100, 2009-2010) and NUH (n = 4068, 2017-2018) cohorts underwent a mid-gestation two and three time-point 75 g 2-hour OGTT, respectively. GDM-related complications (hypertensive disorders of pregnancy, preterm delivery, emergency cesarean section, neonatal intensive care unit admission, macrosomia, birthweight) were compared within shorter and taller groups, dichotomized by ethnic-specific median height.

resultsUsing WHO-1999 criteria, 18.8% (GUSTO) to 22.9% (NUH) of women were diagnosed with GDM-1999; and by WHO-2013 criteria, 21.9% (NUH) had GDM-2013. Each 5-cm height increment was inversely associated with GDM-1999 (adjusted odds ratio [aOR, 95% CI] = 0.81 [0.76-0.87], 2-h glycemia (adjusted β [aβ, 95% CI] = -0.171 mmol/L [-0.208, -0.135]) and 1-h glycemia (aβ = -0.160 mmol/L [-0.207, -0.112]). The inverse association between height and 2-h glycemia was most marked in "Other" ethnicities (Eurasians/Caucasians/mixed/other Asians) and Indians, followed by Chinese, then Malays. Compared with non-GDM, GDM-1999 was associated with preterm delivery (aOR = 1.76 [1.19-2.61]) and higher birthweight (aβ = 57.16 g [20.95, 93.38]) only among taller but not shorter women.

conclusionsOnly taller women had an increased odds of GDM-related pregnancy complications. An artefactual GDM diagnosis due to glucose-overload among shorter women is plausible.

Indexed as

Diabetes, GestationalPregnancy ComplicationsBlood GlucoseCesarean SectionFemaleFetal MacrosomiaGlucose Tolerance TestHumansInfant, NewbornPregnancyPregnancy OutcomeBlood GlucoseBlood glucoseCohort studyGestational diabetes mellitusGlucose tolerance testPregnancy complicationsStanding height

Identifiers

PMID34303772
PMCPMC7611603
OpenAlexW3183596346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.