Evidence map›Paper›PMID 34303522›Full record

ReviewThe Journal of investigative dermatology2021

New Frontiers in Psoriatic Disease Research, Part I: Genetics, Environmental Triggers, Immunology, Pathophysiology, and Precision Medicine.

Di Yan, Johann E Gudjonsson, Stephanie Le, Emanual Maverakis, Olesya Plazyo, Christopher Ritchlin, Jose U Scher, Roopesh Singh, Nicole L Ward, Stacie Bell and 1 more

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of investigative dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Tm4sf19 inhibition alleviates imiquimod-induced psoriatic dermatitis by regulating inflammatory signaling pathways and keratinocyte proliferation in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  6. Review
  7. Review
  8. Psoriasis.Nature reviews. Disease primers · 2025
    Review
  9. Review
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  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Di YanRonald O. Perelman Department of Dermatology, NYU Langone Health, New York, New York, USA.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Stephanie LeDepartment of Dermatology, University of California, Davis, Sacramento, California, USA.
Emanual MaverakisDepartment of Dermatology, University of California, Davis, Sacramento, California, USA.
Olesya PlazyoDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Christopher RitchlinCenter for Musculoskeletal Research, Division of Allergy, Immunology and Rheumatology, University of Rochester School of Medicine & Dentistry, Rochester, New York, USA.
Jose U ScherDepartment of Medicine, NYU Grossman School of Medicine, NYU Langone Health, New York, New York, USA.
Roopesh SinghDepartment of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Nicole L WardDepartment of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA; Department of Dermatology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Stacie BellNational Psoriasis Foundation, Portland, Oregon, USA.
Wilson LiaoUCSF Department of Dermatology, University of California San Francisco, San Francisco, California, USA. Electronic address: wilson.liao@ucsf.edu.
Case Western Reserve University · USUniversity of California, Davis · USUniversity of Michigan · USNational Psoriasis Foundation · USNYU Langone Health · USUniversity of California, San Francisco · USUniversity of Rochester · US

Funding

University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDRZEJ A. DLUGOSZ · 2019 to 2026
$6.6M
Psoriasis Center of Research TranslationP50AR070590 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI WARD, NICOLE LEANNE · 2017 to 2021
$6.5M
TRAINING PROGRAM IN CELL AND MOLECULAR DERMATOLOGYT32AR007197 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAMES TILFORD ELDER, Sunny Y Wong · 1986 to 2026
$4.2M
Employing the gut microbiome to accelerate effective initiation of rheumatoid arthritis therapyR01AR074500 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Renuka Rajendra Nayak, Jose U. Scher · 2019 to 2026
$4.1M
MHC and KIR Region Genomics in PsoriasisU01AI119125 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON · 2015 to 2019
$3.5M
Kallikrein-PAR interactions in skin inflammationR01AR073196 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARD, NICOLE LEANNE · 2018 to 2023
$3.3M
Role of IL-13 and the IL-13 Associated rs20541 Risk Variant in the Pathogenesis of PsoriasisR01AR069071 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUDJONSSON, JOHANN ELI · 2015 to 2019
$2.1M
DC-STAMP: Regulator of Osteoclastogenesis and Response Marker in PsAR01AR069000 · NIAMS · UNIVERSITY OF ROCHESTER · PI RITCHLIN, CHRISTOPHER TREVOR · 2016 to 2020
$1.7M
Role of the Psoriasis Associated IL23R Risk Variants on Th17 Biology and FunctionK08AR060802 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUDJONSSON, JOHANN ELI · 2011 to 2015
$636k
NIAID NIH HHS U01 AI119125NIAMS NIH HHS K08 AR060802NIAMS NIH HHS P30 AR075043NIAMS NIH HHS P50 AR070590NIAMS NIH HHS R01 AR069000NIAMS NIH HHS R01 AR069071NIAMS NIH HHS R01 AR073196NIAMS NIH HHS R01 AR074500NIAMS NIH HHS T32 AR007197
6 · The paper itself

Abstract

Psoriasis is a chronic inflammatory condition characterized by systemic immune dysregulation. Over the past several years, advances in genetics, microbiology, immunology, and mouse models have revealed the complex interplay between the heritable and microenvironmental factors that drive the development of psoriatic inflammation. In the first of this two-part review series, the authors will discuss the newest insights into the pathogenesis of psoriatic disease and highlight how the evolution of these scientific fields has paved the way for a more personalized approach to psoriatic disease treatment.

Indexed as

AnimalsGene-Environment InteractionHumansInflammationPrecision MedicinePsoriasisSkin

Identifiers

PMID34303522
PMCPMC8384663
OpenAlexW3185839749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.