Evidence map›Paper›PMID 34303264›Full record

ArticleCell calcium2021

TRP channels: Intestinal bloating TRiPs up pathogen avoidance.

Elizabeth A Ronan, Rui Xiao, X Z Shawn Xu

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Elizabeth A RonanLife Sciences Institute, University of Michigan, Ann Arbor 48109, United States; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor 48109, United States.
Rui XiaoDepartment of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, FL 32610, United States. Electronic address: rxiao@ufl.edu.
X Z Shawn XuLife Sciences Institute, University of Michigan, Ann Arbor 48109, United States; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor 48109, United States. Electronic address: shawnxu@umich.edu.

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
Sensory Mechanisms and Disorders - Administrative SupplementT32DC000011 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Michael Thomas Roberts · 1989 to 2026
$9.5M
Neural and genetic mechanisms underlying behavior in C. elegans - Administrative Supplement for Equipment PurchasesR35GM126917 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, SHAWN · 2018 to 2025
$3.3M
An unexpected role of glutamate receptors in the peripheral nervous systemR01NS118769 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUAN, BO, XU, SHAWN · 2020 to 2024
$2.6M
Neural and genetic mechanisms underlying mechanosensation in C. elegansR01DC018167 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YE, BING · 2020 to 2025
$2.3M
Dissecting the mechanisms of Alzheimer's disease (AD)-related smell loss in a C. elegans AD modelR01AG063766 · NIA · UNIVERSITY OF FLORIDA · PI XIAO, RUI · 2019 to 2023
$1.9M
Chemosensation and longevity in C. elegansR01AG067753 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, SHAWN · 2020 to 2024
$1.8M
NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG063766NIA NIH HHS R01 AG067753NIDCD NIH HHS R01 DC018167NIDCD NIH HHS T32 DC000011NIGMS NIH HHS R35 GM126917NINDS NIH HHS R01 NS118769
6 · The paper itself

Abstract

Transient receptor potential (TRP) channels are expressed in many nonneural tissues where their functions are not well known. Using C. elegans as a model, a new study demonstrated that colonization of the Gram-positive pathogenic bacteria E. faecalis in the intestine causes intestinal distention. Two TRPM channels sense such intestinal distension to trigger fast pathogen avoidance behavior, thereby limiting pathogen infection. This work signifies the novel role of TRP channels in gut physiology and pathogen defense.

Indexed as

Caenorhabditis elegans ProteinsTransient Receptor Potential ChannelsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsTransient Receptor Potential ChannelsBehavioral immunityChemosensationgon-2gtl-2MechanosensationPathogen defense

Identifiers

PMID34303264
PMCPMC8419106

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.