ReviewCurrent opinion in biotechnology2022
Cytochromes P450 in the biocatalytic valorization of lignin.
Review in Current opinion in biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Sensitive Methanol and Formaldehyde Detection in Enzyme Assays Shows Applicability to Diverse Sample Matrices.ACS omega · 2026Article
- Characterization of acetovanillone degradation in wild-type and engineeredApplied and environmental microbiology · 2026Article
- Whole-Genome Analysis and Lignin Degradation Characterization of Termite-DerivedMicroorganisms · 2025Article
- Multiscale metabolic engineering in biological lignin valorization.Innovation (Cambridge (Mass.)) · 2025Review
- Enhanced chlorogenic acid production from glucose via systematic metabolic engineering ofSynthetic and systems biotechnology · 2025Article
- Structural insights into S-lignin O-demethylation via a rare class of heme peroxygenase enzymes.Nature communications · 2025Article
- Genome-wide identification and expression analysis ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Biocatalytic Strategies for Nitration Reactions.JACS Au · 2025Review
- Characterization of a cytochrome P450 that catalyzes the O-demethylation of lignin-derived benzoates.The Journal of biological chemistry · 2024Article
- Resolving the metabolism of monolignols and other lignin-related aromatic compounds in Xanthomonas citri.Nature communications · 2024Article
- Genomic insight intoHeliyon · 2024Article
- Transcriptomic and metabolomic analysis reveals the influence of carbohydrates on lignin degradation mediated byFrontiers in microbiology · 2024Article
- Synergistic lignin degradation between Phanerochaete chrysosporium and Fenton chemistry is mediated through iron cycling and ligninolytic enzyme induction.The Science of the total environment · 2023Article
- Multisite photocatalytic depolymerization of lignin model compound utilizing full-spectrum light over magnetic microspheres.iScience · 2023Article
- A keyApplied and environmental microbiology · 2023Article
- Bio-Based Valorization of Lignin-Derived Phenolic Compounds: A Review.Biomolecules · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
The valorization of lignin is critical to establishing sustainable biorefineries as we transition away from petroleum-derived feedstocks. Advances in lignin fractionation and depolymerization are yielding new opportunities for the biocatalytic upgrading of lignin-derived aromatic compounds (LDACs) using microbial cell factories. Given their roles in lignin metabolism and their catalytic versatility, cytochromes P450 are attractive enzymes in engineering such biocatalysts. Here we highlight P450s that catalyze aromatic O-demethylation, a rate-limiting step in the conversion of LDACs to valuable chemicals, including efforts to engineer the specificity of these enzymes and to use them in developing biocatalysts. We also discuss broader opportunities at the intersection of biochemistry, structure-guided enzyme engineering, and metabolic engineering for application of P450s in the emerging area of microbial lignin valorization.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.