ArticleBiochemical pharmacology2021
Multipurpose peptides: The venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities.
Article in Biochemical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Venom composition of the ant Tetraponera rufonigra reveals insights into the evolution of dimeric ant venom peptides.Cellular and molecular life sciences : CMLS · 2026Article
- Beyond formic acid: Peptides in carpenter ant venoms aid in disease protection.Science advances · 2026Article
- Molecular Mechanisms of Venom Diversity.Toxins · 2025Review
- The Role of Flexibility in the Bioactivity of Short α-Helical Antimicrobial Peptides.Antibiotics (Basel, Switzerland) · 2025Review
- A review of the venom microbiome and its utility in ecology and evolution including future directions for emerging research.Symbiosis (Philadelphia, Pa.) · 2025Article
- Adaptive trade-offs between vertebrate defence and insect predation drive Amazonian ant venom evolution.Proceedings. Biological sciences · 2024Article
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- The Helix Ring Peptide UMembranes · 2024Article
- Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants.The Journal of biological chemistry · 2024Article
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- Review
- Review
- The mechanism underlying toxicity of a venom peptide against insects reveals how ants are master at disrupting membranes.iScience · 2023Article
- Article
- Profiling hymenopteran venom toxins: Protein families, structural landscape, biological activities, and pharmacological benefits.Toxicon: X · 2022Article
- Venomics of the Central European Myrmicine AntsToxins · 2022Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 5 countries.
Funding
Abstract
In the face of increasing drug resistance, the development of new anthelmintics is critical for controlling nematodes that parasitise livestock. Although hymenopteran venom toxins have attracted attention for applications in agriculture and medicine, few studies have explored their potential as anthelmintics. Here we assessed hymenopteran venoms as a possible source of new anthelmintic compounds by screening a panel of ten hymenopteran venoms against Haemonchus contortus, a major pathogenic nematode of ruminants. Using bioassay-guided fractionation coupled with liquid chromatography-tandem mass spectrometry, we identified four novel anthelmintic peptides (ponericins) from the venom of the neotropical ant Neoponera commutata and the previously described ponericin M-PONTX-Na1b from Neoponera apicalis venom. These peptides inhibit H. contortus development with IC
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