SynthesisAmerican journal of obstetrics and gynecology2022
SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.
Synthesis in American journal of obstetrics and gynecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07257952 (An Observational Study on the Risk of Adverse Maternal and Infant Outcomes Associated With Respiratory Viral Infections Before and During Early Pregnancy), which is not on this map. Cited by 158 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Observational Study on the Risk of Adverse Maternal and Infant Outcomes Associated With Respiratory Viral Infections Before and During Early Pregnancy
Who cites it
158 citing papers in PubMed, 3 syntheses or guidelines pooled it, 275 citations in OpenAlex.
- The impact of COVID-19 infections on pregnancy outcomes in women.BMC pregnancy and childbirth · 2024Pooled it
- Pooled it
- Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis.American journal of obstetrics & gynecology MFM · 2021Pooled it
- Implementation of First-Trimester Screening and Prevention of Preeclampsia: A Stepped Wedge Cluster-Randomized Trial in Asia.Circulation · 2024Trial
- Trial
- Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 Omicron infection: a target trial emulation.Nature medicine · 2024Trial
- Omicron SARS-CoV-2 maternal infection is associated with favorable fetomaternal outcomes and fewer placental vascular malperfusion lesions compared with previous variants.AJOG global reports · 2026Article
- The decade of double-trouble: live birth and stillbirth sex ratio variation in Finland during the COVID-19 pandemic and Russia's attack on Ukraine.European journal of epidemiology · 2026Article
- Preimplantation exposure to viral dsRNA impairs decidualization leading to altered placental development and fetal growth restriction.Reproduction & fertility · 2026Article
- SARS-CoV-2 Infection Exacerbates Hypertensive Disorders in Pregnancy Through Vascular and Immune Pathways.International journal of molecular sciences · 2026Article
- The MRI two-perfusion IVIM model improves understanding of SARS-CoV-2 virus impact on placental tissue.Magma (New York, N.Y.) · 2026Article
- Policy Responses to the COVID-19 Pandemic in High-Income Countries and the Associated Maternal-Infant Health Outcomes: A Systematic Literature and Policy Review.Health science reports · 2026Review
- Higher expression of SOX1, miR-155, and miR-21 in the colostrum of SARS-CoV-2-infected mothers.Scientific reports · 2026Article
- COVID-19 and Pregnancy: Key Findings.Scandinavian journal of immunology · 2026Review
- Infection with SARS-CoV-2 during pregnancy and perinatal death or neonatal intensive care admission: population-based cohort study.BMJ paediatrics open · 2026Article
- Abnormal Pro-inflammatory Immune Cell Responses Precede Clinical Onset of Hypertensive Disorders of Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Review
- COVID-19 vaccination during or just prior to pregnancy and hypertensive disorders of pregnancy.Vaccine · 2026Article
- Stillbirths in Colombia before and during the COVID-19 pandemic: analysis by geographic location and health insurance.BMC public health · 2026Article
- The impact of the COVID-19 pandemic on the diagnosis and management of pre-eclampsia: Identifying healthcare delays.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
98 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine the relationship between SARS-CoV-2 infection during pregnancy and the risk for preeclampsia. DATA SOURCES: MEDLINE, Embase, POPLINE, CINAHL, LILACS, and the World Health Organization COVID-19, Chinese, and preprint databases (all from December 1, 2019, to May 31, 2021). Google Scholar, bibliographies, and conference proceedings were also searched. STUDY ELIGIBILITY CRITERIA: Observational studies that assessed the association between SARS-CoV-2 infection during pregnancy and preeclampsia and that reported unadjusted and/or adjusted risk estimates and 95% confidence intervals or data to calculate them. STUDY APPRAISAL AND SYNTHESIS
methodsThe primary outcome was preeclampsia. Secondary outcomes included preeclampsia with severe features, preeclampsia without severe features, eclampsia, and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. Two reviewers independently reviewed studies for inclusion, assessed their risk of bias, and extracted data. Pooled unadjusted and adjusted odds ratios with 95% confidence intervals, and 95% prediction interval were calculated. Heterogeneity was quantified using the І
resultsA total of 28 studies comprising 790,954 pregnant women, among which 15,524 were diagnosed with SARS-CoV-2 infection, met the inclusion criteria. The meta-analysis of unadjusted odds ratios showed that the odds of developing preeclampsia were significantly higher among pregnant women with SARS-CoV-2 infection than among those without SARS-CoV-2 infection (7.0% vs 4.8%; pooled odds ratio, 1.62; 95% confidence interval, 1.45-1.82; P<.00001; І
conclusionSARS-CoV-2 during pregnancy is associated with higher odds of preeclampsia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.