Evidence map›Paper›PMID 34302743›Full record

ArticleCurrent biology : CB2021

Reinforcement learning links spontaneous cortical dopamine impulses to reward.

Conrad Foo, Adrian Lozada, Johnatan Aljadeff, Yulong Li, Jing W Wang, Paul A Slesinger, David Kleinfeld

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Genetically encoded sensors illuminateIBRO neuroscience reports · 2025
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Conrad FooDepartment of Physics, University of California at San Diego, La Jolla, CA 92093, USA.
Adrian LozadaDepartment of Physics, University of California at San Diego, La Jolla, CA 92093, USA.
Johnatan AljadeffSection of Neurobiology, University of California at San Diego, La Jolla, CA 92093, USA.
Yulong LiPeking University, School of Life Sciences, Peking University, Beijing 100871, P.R. China.
Jing W WangSection of Neurobiology, University of California at San Diego, La Jolla, CA 92093, USA.
Paul A SlesingerDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: paul.slesinger@mssm.edu.
David KleinfeldDepartment of Physics, University of California at San Diego, La Jolla, CA 92093, USA; Section of Neurobiology, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address: dk@physics.ucsd.edu.

Funding

Theory and Modeling of the Orofacial Active SensationU19NS107466 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLOMB, DAVID · 2018 to 2022
$14.9M
Resilient versus fragile aspects of blood flow in the mammalian brainR35NS097265 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2017 to 2024
$6.8M
Synaptic Modulation in Neural CircuitsR01DC009597 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, JING W · 2008 to 2017
$3.1M
Realization of Optical Cell-based Reporters for in vivo Detection of NeuropeptidesR01MH111499 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KLEINFELD, DAVID, SLESINGER, PAUL A · 2016 to 2018
$2.8M
Effects of intrinsic and drug-induced neuromodulation on functional brain imagingR01DA050159 · NIDA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI DEVOR, ANNA · 2020 to 2024
$1.9M
NIDA NIH HHS R01 DA050159NIDCD NIH HHS R01 DC009597NIMH NIH HHS R01 MH111499NINDS NIH HHS R35 NS097265NINDS NIH HHS U19 NS107466
6 · The paper itself

Abstract

In their pioneering study on dopamine release, Romo and Schultz speculated "...that the amount of dopamine released by unmodulated spontaneous impulse activity exerts a tonic, permissive influence on neuronal processes more actively engaged in preparation of self-initiated movements...."

Indexed as

DopamineRewardAnimalsDopaminergic NeuronsLearningMiceReinforcement, PsychologyDopaminebiophysical modelingbrain machine interfaceclassical conditioningfeedbackforagingneuromodulationstochastic dynamicstwo-photon microscopy

Identifiers

PMID34302743
PMCPMC8605927

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.