Evidence map›Paper›PMID 34302742›Full record

ArticleCurrent biology : CB2021

Striatal low-threshold spiking interneurons locally gate dopamine.

Elizabeth N Holly, M Felicia Davatolhagh, Rodrigo A España, Marc V Fuccillo

Open access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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  5. Local Regulation of Striatal Dopamine Release Shifts from Predominantly Cholinergic in Mice to GABAergic in Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Elizabeth N HollyDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: eholly@pennmedicine.upenn.edu.
M Felicia DavatolhaghDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rodrigo A EspañaDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
Marc V FuccilloDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: fuccillo@pennmedicine.upenn.edu.
University of Pennsylvania · USDrexel University · US

Funding

A Novel Role for Local Striatal Interneuron Regulation of Goal-Directed ActionR01MH118369 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FUCCILLO, MARC V · 2020 to 2024
$2.8M
Linking Synaptic and Cognitive Deficits in a Model of Neuropsychiatric DiseaseR00MH099243 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FUCCILLO, MARC V · 2015 to 2017
$711k
Role of dorsomedial striatum low-threshold spiking interneurons in goal-directed behaviorF32MH114506 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI HOLLY, ELIZABETH N. · 2017 to 2019
$184k
NIMH NIH HHS F32 MH114506NIMH NIH HHS R00 MH099243NIMH NIH HHS R01 MH118369
6 · The paper itself

Abstract

The dorsomedial striatum (DMS) is a central hub supporting goal-directed learning and motor performance. Recent evidence has revealed unexpected roles for local inhibitory GABAergic networks in modulating striatal output and behavior.

Indexed as

Corpus StriatumDopamineInterneuronsLearningRewardDopaminearipiprazoledopaminedorsal striatumdorsomedial striatumfast scan cyclic voltammetrylow-threshold spiking interneuronsoperant learningsomatostatin interneurons

Identifiers

PMID34302742
PMCPMC8554636
OpenAlexW3183820996

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.