SynthesisArchives of pharmacal research2021
Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis.
Synthesis in Archives of pharmacal research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- A Systematic Review on Neurological Aspects of COVID-19: Exploring the Relationship Between COVID-19-Related Olfactory Dysfunction and Neuroinvasion.Frontiers in neurology · 2022Pooled it
- The D614G Virus Mutation Enhances Anosmia in COVID-19 Patients: Evidence from a Systematic Review and Meta-analysis of Studies from South Asia.ACS chemical neuroscience · 2021Pooled it
- Prevalence and Clinical Factors Associated with Self-reported Smell and Taste Disorders in Older Adults Hospitalized with COVID-19.International archives of otorhinolaryngology · 2025Article
- A comparison of self-reported COVID-19 symptoms between android and iOS CoronaCheck app users.NPJ digital medicine · 2025Article
- Observational
- Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection.Nature communications · 2025Article
- Vaccination prior to SARS-CoV-2 infection does not affect the neurologic manifestations of long COVID.Brain communications · 2025Article
- Predicting Intensive Care Unit Admission in COVID-19-Infected Pregnant Women Using Machine Learning.Journal of clinical medicine · 2024Article
- Article
- Analysis and comparative evaluation of expedited programs for gene therapy products: insights from the United States, the European Union, Japan, and South Korea.Gene therapy · 2024Article
- The Prognostic Value of Olfactory Dysfunction in Patients with COVID-19: The COVIDORA Study.Life (Basel, Switzerland) · 2024Article
- Article
- Clinical presentation and pulmonary function tests in post-acute COVID-19 patients.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2023Article
- Neurological manifestations in SARS-CoV-2 infection: A single-center cross-sectional study in Malaysia.Neurology and clinical neuroscience · 2023Article
- Frequency and burden of neurological manifestations upon hospital presentation in COVID-19 patients: Findings from a large Brazilian cohort.Journal of the neurological sciences · 2022Article
- Olfactory dysfunction in COVID-19, new insights from a cohort of 353 patients: The ANOSVID study.Journal of medical virology · 2022Article
- Review
- The Prevalence and Implications of Olfactory/Gustatory Dysfunctions among Adult COVID-19 Patients: A Retrospective Cohort Multiethnic Populations Study.Tropical medicine and infectious disease · 2022Article
- Physiological plausibility of lower viral load in patients with COVID-19 and olfactory/gustatory dysfunction.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2022Article
- Trends in Ambulatory Analgesic Usage after Myocardial Infarction: A Nationwide Cross-Sectional Study of Real-World Data.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Anecdotal evidence suggests that the severity of coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is likely to be distinguished by variations in loss of smell (LOS). Thus, we conducted a meta-analysis of 45 articles that include a total of 42,120 COVID-19 patients from 17 different countries to demonstrate that severely ill or hospitalized COVID-19 patients have a lesser chance of experiencing LOS than non-severely ill or non-hospitalized COVID-19 patients (odds ratio = 0.527 [95% CI 0.373-0.744; p < 0.001] and 0.283 [95% CI 0.173-0.462; p < 0.001], respectively). We also proposed a possible mechanism underlying the association of COVID-19 severity with anosmia, which may explain why patients without sense of smell develop severe COVID-19. Variations in LOS according to the severity of COVID-19 is a global phenomenon, with few exceptions. Since severely ill patients have a lower rate of anosmia, patients without anosmia should be monitored more closely in the early stages of COVID-19, for early diagnosis of severity of illness. An understanding of how the severity of COVID-19 infection and LOS are associated has profound implications for the clinical management and mitigation strategies for the disease.
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Registered trials
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