Evidence map›Paper›PMID 34302617›Full record

ArticleNeuroscience bulletin2021

cFos-ANAB: A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors.

Fan Wang, Wenjie Sun, Lei Chang, Kefang Sun, Leying Hou, Linna Qian, Chaoyin Jin, Jiandong Chen, Jiali Pu, Panmeng Ye and 6 more

Open access · greenAbstract read
In one paragraph

Article in Neuroscience bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Fan WangCenter for Neuroscience and Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Wenjie SunMedical Information Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Lei ChangMedical Information Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Kefang SunMedical Information Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Leying HouMedical Information Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Linna QianMedical Information Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Chaoyin JinMedical Information Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Jiandong ChenMedical Information Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Jiali PuDepartment of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Panmeng YeHangzhou Hikvision Digital Technology Co., Ltd, Hangzhou, 310053, China.
Shuang QiuCenter for Neuroscience and Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Jianhong LuoCenter for Neuroscience and Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.ORCID http://orcid.org/0000-0001-7832-496X
Shumin DuanCenter for Neuroscience and Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Baorong ZhangDepartment of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. brzhang@zju.edu.cn.
Zhihua GaoCenter for Neuroscience and Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. zhihuagao@zju.edu.cn.ORCID http://orcid.org/0000-0001-8603-0777
Xiaojun HuMedical Information Center, Zhejiang University School of Medicine, Hangzhou, 310058, China. xjhu@zju.edu.cn.
Second Affiliated Hospital of Zhejiang University · CNZhejiang University · CNHikvision (China)Zhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

cFos is one of the most widely-studied genes in the field of neuroscience. Currently, there is no systematic database focusing on cFos in neuroscience. We developed a curated database-cFos-ANAB-a cFos-based web tool for exploring activated neurons and associated behaviors in rats and mice, comprising 398 brain nuclei and sub-nuclei, and five associated behaviors: pain, fear, feeding, aggression, and sexual behavior. Direct relationships among behaviors and nuclei (even cell types) under specific stimulating conditions were constructed based on cFos expression profiles extracted from original publications. Moreover, overlapping nuclei and sub-nuclei with potentially complex functions among different associated behaviors were emphasized, leading to results serving as important clues to the development of valid hypotheses for exploring as yet unknown circuits. Using the analysis function of cFos-ANAB, multi-layered pictures of networks and their relationships can quickly be explored depending on users' purposes. These features provide a useful tool and good reference for early exploration in neuroscience. The cFos-ANAB database is available at www.cfos-db.net .

Indexed as

NeuronsProto-Oncogene Proteins c-fosAnimalsFearMiceRatsProto-Oncogene Proteins c-fosBehaviorBrain nucleuscFos expressionCurated databaseStimulusVisualization tools

Identifiers

PMID34302617
PMCPMC8490591
OpenAlexW3183652900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.