Evidence map›Paper›PMID 34302599›Full record

ArticleLa Radiologia medica2021

Multireader comparison of contrast-enhanced mammography versus the combination of digital mammography and digital breast tomosynthesis in the preoperative assessment of breast cancer.

Rossano Girometti, Anna Linda, Paola Conte, Michele Lorenzon, Isabella De Serio, Katerina Jerman, Viviana Londero, Chiara Zuiani

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in La Radiologia medica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. State-of-the-art for contrast-enhanced mammography.The British journal of radiology · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Gender Medicine in Clinical Radiology Practice.Journal of personalized medicine · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Rossano GiromettiDepartment of Medicine, Institute of Radiology, University of Udine, University Hospital S. Maria Della Misericordia, p.le S. Maria della Misericordia n. 15, 33100, Udine, Italy.ORCID http://orcid.org/0000-0002-0904-5147
Anna LindaInstitute of Radiology, University Hospital S. Maria della Misericordia, p.le S. Maria della Misericordia n. 15, 33100, Udine, Italy.
Paola ConteInstitute of Radiology, University Hospital S. Maria della Misericordia, p.le S. Maria della Misericordia n. 15, 33100, Udine, Italy.
Michele LorenzonInstitute of Radiology, University Hospital S. Maria della Misericordia, p.le S. Maria della Misericordia n. 15, 33100, Udine, Italy.
Isabella De SerioDepartment of Medicine, Institute of Radiology, University of Udine, University Hospital S. Maria Della Misericordia, p.le S. Maria della Misericordia n. 15, 33100, Udine, Italy.
Katerina JermanDepartment of Medicine, Institute of Radiology, University of Udine, University Hospital S. Maria Della Misericordia, p.le S. Maria della Misericordia n. 15, 33100, Udine, Italy.
Viviana LonderoInstitute of Radiology, University Hospital S. Maria della Misericordia, p.le S. Maria della Misericordia n. 15, 33100, Udine, Italy.
Chiara ZuianiDepartment of Medicine, Institute of Radiology, University of Udine, University Hospital S. Maria Della Misericordia, p.le S. Maria della Misericordia n. 15, 33100, Udine, Italy. chiara.zuiani@uniud.it.
Ospedale Santa Maria della Misericordia di Udine · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare preoperative contrast-enhanced spectral mammography (CEM) versus digital mammography plus digital breast tomosynthesis (DM + DBT) in detecting breast cancer (BC) and assessing its size. MATERIAL AND

methodsWe retrospectively included 78 patients with histological diagnosis of BC who underwent preoperative DM, DBT, and CEM over one year. Four readers, blinded to pathology and clinical information, independently evaluated DM + DBT versus CEM to detect BC and measure its size. Readers' experience ranged 3-10 years. We calculated the per-lesion cancer detection rate (CDR) and the complement of positive predictive value (1-PPV) of both methods, stratifying analysis on the total of lesions, index lesions, and additional lesions. The agreement in assessing cancer size versus pathology was assessed with Bland-Altman analysis.

results100 invasive BCs (78 index lesions and 22 additional lesions) were analyzed. Compared to DM + DBT, CEM showed higher overall CDR in less experienced readers (range 0.85-0.90 vs. 0.95-0.96), and higher CDR for additional lesions, regardless of the reader (range 0.54-0.68 vs. 0.77-0.86). CEM increased the detection of additional disease in dense breasts in all readers and non-dense breasts in less experienced readers only. The 1-PPV of CEM (range 0.10-0.18) was comparable to that of DM + DBT (range 0.09-0.19). At Bland-Altman analysis, DM + DBT and CEM showed comparable mean differences and limits of agreement in respect of pathologic cancer size.

conclusionPreoperative CEM improved the detection of additional cancer lesions compared to DM + DBT, particularly in dense breasts. CEM and DM + DBT achieved comparable performance in cancer size assessment.

Indexed as

Contrast MediaAgedAged, 80 and overBreast NeoplasmsFemaleHumansMammographyMiddle AgedObserver VariationPreoperative PeriodRadiographic Image EnhancementRetrospective StudiesContrast MediaBreast cancerContrast-enhanced digital mammographyDigital breast tomosynthesisDigital mammographyPreoperative staging

Identifiers

PMID34302599
OpenAlexW3186451360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.