Evidence map›Paper›PMID 34302572›Full record

ArticleOral radiology2022

Stiffness of tongue squamous cell carcinoma measured using strain elastography correlates with the amount of collagen fibers in the tumor.

Mari Shibata, Ayataka Ishikawa, Junichi Ishii, Eri Anzai, Hisao Yagishita, Toshiyuki Izumo, Jun Sumino, Miki Katsurano, Yusoon Kim, Hiroaki Kanda and 3 more

Erratum issuedAbstract read
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In one paragraph

Article in Oral radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Mari ShibataDepartment of Oral Surgery, Saitama Cancer Center, Saitama, Japan.ORCID http://orcid.org/0000-0001-7497-9184
Ayataka IshikawaDepartment of Pathology, Saitama Cancer Center, Saitama, Japan. ayataka@cancer-c.pref.saitama.jp.ORCID http://orcid.org/0000-0002-7989-2333
Junichi IshiiDepartment of Oral Surgery, Saitama Cancer Center, Saitama, Japan.ORCID http://orcid.org/0000-0002-9368-3925
Eri AnzaiDepartment of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6075-7537
Hisao YagishitaDepartment of Pathology, Saitama Cancer Center, Saitama, Japan.ORCID http://orcid.org/0000-0003-4697-5092
Toshiyuki IzumoDepartment of Pathology, Saitama Cancer Center, Saitama, Japan.ORCID http://orcid.org/0000-0001-8601-0434
Jun SuminoDepartment of Oral Surgery, Saitama Cancer Center, Saitama, Japan.ORCID http://orcid.org/0000-0002-2744-2146
Miki KatsuranoDepartment of Oral Surgery, Saitama Cancer Center, Saitama, Japan.ORCID http://orcid.org/0000-0002-1772-1838
Yusoon KimDepartment of Oral Surgery, Saitama Cancer Center, Saitama, Japan.ORCID http://orcid.org/0000-0002-8304-9488
Hiroaki KandaDepartment of Pathology, Saitama Cancer Center, Saitama, Japan.ORCID http://orcid.org/0000-0002-4602-5938
Masaru UshijimaClinical Research and Medical Development Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.ORCID http://orcid.org/0000-0001-6383-8482
Kazuhiro YagiharaDepartment of Oral Surgery, Saitama Cancer Center, Saitama, Japan.ORCID http://orcid.org/0000-0002-9166-6937
Tetsuya YodaDepartment of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.ORCID http://orcid.org/0000-0003-1896-8696
Saitama Cancer Center · JPTokyo Medical and Dental University · JPJapanese Foundation For Cancer Research · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the stiffness of tongue squamous cell carcinoma (TSCC) using ultrasound strain elastography, a relatively new sonographic imaging technique, and to identify the factors that affect this stiffness.

methodsWe treated 62 patients diagnosed with muscle invasive TSCC, who were treated at the department of oral surgery of our institution. Each patient's tumor stiffness was semi-quantified according to the ratio of cancer to tongue muscle strain measured using ultrasound strain elastography (the strain ratio). Histopathological diagnosis was made on the same section as the ultrasound strain elastography. We set the following histopathological parameters: cancer cell content in the tumor area (%CCC), collagen fiber content in the tumor area (%CFC), and tumor-infiltrating inflammatory cell content in the stromal compartment (%TIIC). Spearman's rank correlation (rs) was used to assess correlations, and P values < 0.05 were considered significant.

resultsThe mean strain ratio was 9.7 ± 9.8. The mean %CCC was 38.4 ± 11.3%, and % CFC was 31.1 ± 7.8%, % TIICs was 19.9 ± 8.9%. Log (strain ratio) by ultrasound strain elastography was positively correlated with %CFC (r

conclusionThe strain ratio of the cancer to the strain of the tongue muscle measured through ultrasound strain elastography positively correlates with the collagen fiber content of the tumor area.

Indexed as

Carcinoma, Squamous CellElasticity Imaging TechniquesTongue NeoplasmsCollagenHumansTongueCollagenCollagen fibersStrain elastographyStrain ratioTongue cancerTongue stiffnessUltrasound strain elastography

Identifiers

PMID34302572
OpenAlexW3186178292

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.