Observational studyIntensive care medicine2021
Management of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI study.
Observational study in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of mortality and neurological outcomes with hypocapnia in adult patients with acute brain injury: an updated meta-analysis.Critical care (London, England) · 2026Pooled it
- Mechanical ventilation in acute brain injury.Breathe (Sheffield, England) · 2026Review
- Mechanical Ventilation Practices in Traumatic Brain Injury: A Systematic Review of Contemporary Evidence.Cureus · 2026Review
- First Breath Matters: Out-of-Hospital Mechanical Ventilation in Patients with Traumatic Brain Injury.Journal of clinical medicine · 2025Review
- Brain Protective Ventilation Strategies in Severe Acute Brain Injury.Current neurology and neuroscience reports · 2025Review
- Latent class growth analysis of dynamic PaCoScientific reports · 2025Article
- Variation in Arterial CO2 is a Stronger Determinant of Brain Tissue Oxygenation Than its Synchronous Value in Critically Ill Patients With Acute Brain Injury.Critical care explorations · 2025Article
- Observational
- Organ crosstalk: brain-lung interaction.Frontiers in medicine · 2025Review
- An Overview of Adult Acute Traumatic Neurologic Injury for the Anesthesiologist:Current anesthesiology reports · 2025Article
- PaCONeurocritical care · 2024Article
- Short-term mild hyperventilation on intracranial pressure, cerebral autoregulation, and oxygenation in acute brain injury patients: a prospective observational study.Journal of clinical monitoring and computing · 2024Observational
- Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study.Intensive care medicine · 2024Observational
- PaCO2 Association with Traumatic Brain Injury Patients Outcomes at High Altitude: A Prospective Single-Center Cohort Study.Research square · 2024Article
- Are We Ready for Clinical Therapy based on Cerebral Autoregulation? A Pro-con Debate.Neurocritical care · 2023Article
- Hypocapnia is an independent predictor of in-hospital mortality in acute heart failure.ESC heart failure · 2023Article
- The establishment and validation of a prediction model for traumatic intracranial injury patients: a reliable nomogram.Frontiers in neurology · 2023Article
- Treatments for intracranial hypertension in acute brain-injured patients: grading, timing, and association with outcome. Data from the SYNAPSE-ICU study.Intensive care medicine · 2023Observational
- Traumatic brain injury: progress and challenges in prevention, clinical care, and research.The Lancet. Neurology · 2022Review
- Moderate hypocapnia for intracranial pressure control after traumatic brain injury: a common practice requiring further investigations.Intensive care medicine · 2021Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe the management of arterial partial pressure of carbon dioxide (PaCO
methodsSecondary analysis of CENTER-TBI, a multicentre, prospective, observational, cohort study. The primary aim was to describe current practice in PaCO
resultsWe included 1100 patients, with a total of 11,791 measurements of PaCO
conclusionsVentilation is manipulated differently among centers and in response to intracranial dynamics. PaCO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.