SynthesisSkeletal radiology2022
Diagnostic performance of MRI and CT in diagnosing necrotizing soft tissue infection: a systematic review.
Synthesis in Skeletal radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Comments on "A Case of Necrotizing Fasciitis That Rapidly Progressed after a Minor Injury".Journal of plastic and reconstructive surgery · 2026Article
- Discovery of a Thermostable Nigerose Phosphorylase for the Efficient Chemoenzymatic Radiosynthesis of aJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- CT of Soft Tissue Infections: Current and Future Perspectives from Diagnosis to Treatment.Journal of clinical medicine · 2026Review
- Melioidosis with non-necrotising diffuse cellulitis and intramuscular abscesses of the trunk mimicking necrotising soft tissue infection: a case report.BMC infectious diseases · 2026Article
- Fatal Necrotizing Fasciitis Caused by Pasteurella multocida Without Cutaneous Findings: When Pain Is the Clue.Cureus · 2026Article
- Host-response trajectories in necrotizing fasciitis: host-pathogen interactions, immune evasion, and immunoparalysis.Frontiers in cellular and infection microbiology · 2026Review
- Article
- Characteristics, treatments, and outcomes of patients with necrotizing soft tissue infections: a Dutch multicenter cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Predictors of clinical outcomes in necrotizing fasciitis: a ten year study.International orthopaedics · 2025Article
- Complicated and deep bacterial skin and soft tissue infections.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Review
- Case Report: From septic shock to recovery - a battle against lethal necrotizing soft tissue infection.Frontiers in immunology · 2025Article
- Predicting mortality in necrotizing fasciitis: Retrospective evaluation of 69 cases.Northern clinics of Istanbul · 2025Article
- Imaging features of soft-tissue infections.Skeletal radiology · 2024Review
- Approach to imaging modalities in the setting of suspected infection.Skeletal radiology · 2024Review
- Lower extremity infections: Essential anatomy and multimodality imaging findings.Skeletal radiology · 2024Review
- No role for standard imaging workup of patients with clinically evident necrotizing soft tissue infections: a national retrospective multicenter cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Real-time identification of life-threatening necrotizing soft-tissue infections using indocyanine green fluorescence imaging.Journal of biomedical optics · 2024Observational
- Article
- Theoretical Design and Synthesis of Caged Compounds Using X-Ray-Triggered Azo Bond Cleavage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Emergency department referrals for CT imaging of extremity soft tissue infection: before and during the COVID-19 pandemic.BJR open · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo systematically review the accuracy of MRI and CT in diagnosing necrotizing soft tissue infection (NSTI).
methodsMEDLINE and Embase were searched for original studies which reported the diagnostic performance of MRI or CT in detecting NSTI. Individual study quality was assessed using the QUADAS-2 tool. Sensitivity and specificity of MRI and CT were calculated and, if supported by data from at least two studies, pooled using a bivariate random-effects model.
resultsSix MRI studies and 7 CT studies were included. There were no major concerns with regard to study quality and applicability. The included studies used multiple diagnostic criteria, with sensitivities and specificities of both MRI and CT ranging between 0 and 100%. T2 hyperintensity of deep fascia was the most commonly used diagnostic MRI criterion (5 studies), yielding a pooled sensitivity of 86.4% (95% confidence interval [CI] 76.1-92.7%) and a pooled specificity of 65.2% (95% CI 35.4-86.6%). Presence of gas was the most commonly used diagnostic CT criterion (3 studies), yielding a pooled sensitivity of 48.6% (95% CI 37.1-60.2%) and a pooled specificity of 93.2% (95% CI 73.3-98.5%).
conclusionT2 hyperintensity of deep fascia at MRI has high sensitivity and moderate specificity in diagnosing NSTI. Presence of gas at CT has low sensitivity but high specificity. A combination of diagnostic criteria may improve diagnostic performance, but this needs further investigation.
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