ArticleThe Journal of infectious diseases2021
Higher Viral Load Drives Infrequent Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Between Asymptomatic Residence Hall Roommates.
Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed.
- Article
- Modeling the transmission mitigation impact of testing for infectious diseases.Science advances · 2024Article
- Modeling the Transmission Mitigation Impact of Testing for Infectious Diseases.medRxiv : the preprint server for health sciences · 2024Article
- Clinical and virological features of asymptomatic and mild symptomatic patients with SARS-CoV-2 Omicron infection at Shanghai Fangcang shelter hospital.Immunity, inflammation and disease · 2023Observational
- SARS-CoV-2 transmission modes: Why and how contamination occurs around shared meals and drinks?Food microbiology · 2023Review
- Positive feedback loops exacerbate the influence of superspreaders in disease transmission.iScience · 2023Article
- High rates of observed face mask use at Colorado universities align with students' opinions about masking and support the safety and viability of in-person higher education during the COVID-19 pandemic.BMC public health · 2023Article
- SARS-CoV-2 viral load is associated with risk of transmission to household and community contacts.BMC infectious diseases · 2022Article
- Mathematical modeling of respiratory viral infection and applications to SARS-CoV-2 progression.Mathematical methods in the applied sciences · 2022Article
- Article
- SARS-CoV-2 Transmission and Prevention in the Era of the Delta Variant.Infectious disease clinics of North America · 2022Review
- Comparing the Impact of Road Networks on COVID-19 Severity between Delta and Omicron Variants: A Study Based on Greater Sydney (Australia) Suburbs.International journal of environmental research and public health · 2022Article
- SARS-CoV-2 transmission and impacts of unvaccinated-only screening in populations of mixed vaccination status.Nature communications · 2022Article
- SARS-CoV-2 Transmission and Impacts of Unvaccinated-Only Screening in Populations of Mixed Vaccination Status.medRxiv : the preprint server for health sciences · 2022Article
- Indirect Protection by Reducing Transmission: Ending the Pandemic With Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination.Open forum infectious diseases · 2022Article
- Review
- Will the COVID-19 pandemic end with the Delta and Omicron variants?Environmental chemistry letters · 2022Article
- Article
- High-resolution within-sewer SARS-CoV-2 surveillance facilitates informed intervention.Water research · 2021Article
- COVID-19 vaccination: Why extend the interval between doses?Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2021Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundThe coronavirus disease 2019 pandemic spread to >200 countries in <6 months. To understand coronavirus spread, determining transmission rate and defining factors that increase transmission risk are essential. Most cases are asymptomatic, but people with asymptomatic infection have viral loads indistinguishable from those in symptomatic people, and they do transmit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, asymptomatic cases are often undetected.
methodsGiven high residence hall student density, the University of Colorado Boulder established a mandatory weekly screening test program. We analyzed longitudinal data from 6408 students and identified 116 likely transmission events in which a second roommate tested positive within 14 days of the index roommate.
resultsAlthough the infection rate was lower in single-occupancy rooms (10%) than in multiple-occupancy rooms (19%), interroommate transmission occurred only about 20% of the time. Cases were usually asymptomatic at the time of detection. Notably, individuals who likely transmitted had an average viral load approximately 6.5-fold higher than individuals who did not (mean quantification cycle [Cq], 26.2 vs 28.9). Although students with diagnosed SARS-CoV-2 infection moved to isolation rooms, there was no difference in time to isolation between cases with or without interroommate transmission.
conclusionsThis analysis argues that interroommate transmission occurs infrequently in residence halls and provides strong correlative evidence that viral load is proportional to transmission probability.
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