ArticleHuman brain mapping2021
Brain structural connectivity, anhedonia, and phenotypes of major depressive disorder: A structural equation model approach.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- An Exploratory Comparison of Alpha and Beta Network Connectivity Across Four Depression Subtypes.Journal of clinical medicine · 2025Article
- The neurobiology of motivational anhedonia in patients with depression.Brain imaging and behavior · 2025Article
- Fronto-Thalamic Structural Connectivity Associated With Schizotypy, a Psychosis Risk Phenotype, in Nonclinical Subjects.Schizophrenia bulletin · 2025Article
- Structural covariance network patterns linked to neuropsychiatric symptoms in biologically defined Alzheimer's disease: Insights from the mild behavioral impairment checklist.Journal of Alzheimer's disease : JAD · 2025Article
- White matter functional connectome gradient dysfunction in major depressive disorder.Psychoradiology · 2025Article
- Stress resilience is an active and multifactorial process manifested by structural, functional, and molecular changes in synapses.Neurobiology of stress · 2024Article
- White matter microstructure and serum biomarkers of inflammation in psychogenic non-epileptic seizures.NeuroImage. Clinical · 2023Article
- Fractional anisotropy and peripheral cytokine concentrations in outpatients with depressive episode: a diffusion tensor imaging observational study.Scientific reports · 2022Observational
- Discipline Construction and Development of Medical Universities in Complex Environment under Digital Technology and Structural Equation Model.Journal of healthcare engineering · 2022Article
- Brain structural connectivity, anhedonia, and phenotypes of major depressive disorder: A structural equation model approach.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
21 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aberrant brain structural connectivity in major depressive disorder (MDD) has been repeatedly reported, yet many previous studies lack integration of different features of MDD with structural connectivity in multivariate modeling approaches. In n = 595 MDD patients, we used structural equation modeling (SEM) to test the intercorrelations between anhedonia, anxiety, neuroticism, and cognitive control in one comprehensive model. We then separately analyzed diffusion tensor imaging (DTI) connectivity measures in association with those clinical variables, and finally integrated brain connectivity associations, clinical/cognitive variables into a multivariate SEM. We first confirmed our clinical/cognitive SEM. DTI analyses (FWE-corrected) showed a positive correlation of anhedonia with fractional anisotropy (FA) in the right anterior thalamic radiation (ATR) and forceps minor/corpus callosum, while neuroticism was negatively correlated with axial diffusivity (AD) in the left uncinate fasciculus (UF) and inferior fronto-occipital fasciculus (IFOF). An extended SEM confirmed the associations of ATR FA with anhedonia and UF/IFOF AD with neuroticism impacting on cognitive control. Our findings provide evidence for a differential impact of state and trait variables of MDD on brain connectivity and cognition. The multivariate approach shows feasibility of explaining heterogeneity within MDD and tracks this to specific brain circuits, thus adding to better understanding of heterogeneity on the biological level.
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