ArticleStatistics in medicine2021
Penalized regression for left-truncated and right-censored survival data.
Article in Statistics in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The trial behind it
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Who cites it
26 citing papers in PubMed.
- Mismatch repair deficiency, next-generation sequencing-based microsatellite instability, and tumor mutational burden as predictive biomarkers for immune checkpoint inhibitor effectiveness in frontline treatment of advanced stage endometrial cancer.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023Trial
- SPEN inactivation drives resistance to androgen receptor pathway inhibitors in metastatic prostate cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Ultra-high tumor mutation burden breast cancer: genomic profiling and real-world immunotherapy results.NPJ breast cancer · 2026Article
- Prognostic pan-cancer and single-cancer models: A large-scale analysis using a real-world clinico-genomic database.PloS one · 2026Article
- Association of Homologous Recombination Repair Alterations with Outcomes in Patients with Metastatic Hormone-Sensitive Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Prognostic impact of the timing of antihypertensive medication initiation for hypertension detected at health screening on primary prevention of adverse cardiovascular events: Age-stratified real-world data analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Observational
- Utility of plasma circulating DNA tumor fraction in bone-only metastatic breast cancer: a real-world outcomes study.Breast cancer research and treatment · 2025Article
- Effectiveness of PARP Inhibitor Maintenance Therapy in Ovarian Cancer by BRCA1/2 and a Scar-Based HRD Signature in Real-World Practice.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Pan-tumor validation of a NGS fraction-based MSI analysis as a predictor of response to Pembrolizumab.NPJ precision oncology · 2024Article
- Group lasso priors for Bayesian accelerated failure time models with left-truncated and interval-censored data.Statistical methods in medical research · 2024Article
- The Health Impact of Waiting for Elective Procedures in the NHS in England: A Modeling Framework Applied to Coronary Artery Bypass Graft and Total Hip Replacement.Medical decision making : an international journal of the Society for Medical Decision Making · 2024Article
- Toward optimizing patient selection for EGFR antibody therapies in metastatic colorectal cancer: outcomes and resistance features in real-world data.ESMO real world data and digital oncology · 2024Article
- A Bayesian semi-parametric model for learning biomarker trajectories and changepoints in the preclinical phase of Alzheimer's disease.Biometrics · 2024Article
- Systematic analysis of off-label and off-guideline cancer therapy usage in a real-world cohort of 165,912 US patients.Cell reports. Medicine · 2024Article
- Relationship of tumor fraction in circulating tumor DNA with prognosis in patients with advanced urothelial cancer.ESMO real world data and digital oncology · 2024Article
- Article
- A principal-weighted penalized regression model and its application in economic modeling.Journal of applied statistics · 2024Article
- Tumor Mutational Burden in Real-World Patients With Pancreatic Cancer: Genomic Alterations and Predictive Value for Immune Checkpoint Inhibitor Effectiveness.JCO precision oncology · 2023Article
- Borrowing Concurrent Information from Non-Concurrent Control to Enhance Statistical Efficiency in Platform Trials.Current oncology (Toronto, Ont.) · 2023Article
- Durable responders in advanced NSCLC with elevated TMB and treated with 1L immune checkpoint inhibitor: a real-world outcomes analysis.Journal for immunotherapy of cancer · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-dimensional data are becoming increasingly common in the medical field as large volumes of patient information are collected and processed by high-throughput screening, electronic health records, and comprehensive genomic testing. Statistical models that attempt to study the effects of many predictors on survival typically implement feature selection or penalized methods to mitigate the undesirable consequences of overfitting. In some cases survival data are also left-truncated which can give rise to an immortal time bias, but penalized survival methods that adjust for left truncation are not commonly implemented. To address these challenges, we apply a penalized Cox proportional hazards model for left-truncated and right-censored survival data and assess implications of left truncation adjustment on bias and interpretation. We use simulation studies and a high-dimensional, real-world clinico-genomic database to highlight the pitfalls of failing to account for left truncation in survival modeling.
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