Evidence map›Paper›PMID 34302323›Full record

ArticleJournal of biomedical optics2021

Perspectives on interstitial photodynamic therapy for malignant tumors.

Katarzyna Komolibus, Carl Fisher, Johannes Swartling, Sune Svanberg, Katarina Svanberg, Stefan Andersson-Engels

Open access · goldAbstract read
In one paragraph

Article in Journal of biomedical optics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  11. A Monte Carlo simulation for Moving Light Source in Intracavity PDT.Proceedings of SPIE--the International Society for Optical Engineering
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Katarzyna KomolibusTyndall National Institute, Ireland.
Carl FisherTyndall National Institute, Ireland.
Johannes SwartlingSpectraCure AB, Sweden.
Sune SvanbergLund Univ., Sweden.
Katarina SvanbergSouth China Normal Univ., China.
Stefan Andersson-EngelsTyndall National Institute, Ireland.
Tyndall Centre · GBLund University · SESouth China Normal University · CNSpectraCure (Sweden) · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

significanceDespite remarkable advances in the core modalities used in combating cancer, malignant diseases remain the second largest cause of death globally. Interstitial photodynamic therapy (IPDT) has emerged as an alternative approach for the treatment of solid tumors.

aimThe aim of our study is to outline the advancements in IPDT in recent years and provide our vision for the inclusion of IPDT in standard-of-care (SoC) treatment guidelines of specific malignant diseases. APPROACH: First, the SoC treatment for solid tumors is described, and the attractive properties of IPDT are presented. Second, the application of IPDT for selected types of tumors is discussed. Finally, future opportunities are considered.

resultsStrong research efforts in academic, clinical, and industrial settings have led to significant improvements in the current implementation of IPDT, and these studies have demonstrated the unique advantages of this modality for the treatment of solid tumors. It is envisioned that further randomized prospective clinical trials and treatment optimization will enable a wide acceptance of IPDT in the clinical community and inclusion in SoC guidelines for well-defined clinical indications.

conclusionsThe minimally invasive nature of this treatment modality combined with the relatively mild side effects makes IPDT a compelling alternative option for treatment in a number of clinical applications. The adaptability of this technique provides many opportunities to both optimize and personalize the treatment.

Indexed as

NeoplasmsPhotochemotherapyHumansProspective Studiesdosimetryinterstitial photodynamic therapyphotosensitizerssolid tumors

Identifiers

PMID34302323
PMCPMC8299827
OpenAlexW3186958185

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.