Evidence map›Paper›PMID 34302289›Full record

ArticleAdvances in experimental medicine and biology2022

Ultrastructural and Immunohistochemical Diagnosis of a Neonatal Herpes Simplex Virus Infection Presenting as Fulminant Hepatitis: A Case Report.

Valentina Papa, Nunzio Cosimo Mario Salfi, Roberta Costa, Ilaria Bettocchi, Emilia Ricci, Duccio Maria Cordelli, Francesca Locatelli, Fabio Caramelli, Giovanna Cenacchi

Erratum issuedAbstract readCase Reports
PubMed Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Valentina PapaDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Nunzio Cosimo Mario SalfiPathology Unit, Integrated Department of Services and Laboratories, Pathological Anatomy Unit, IRCCS Giannina Gaslini Institute, Genova, Italy formerly at Pathology Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
Roberta CostaDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Ilaria BettocchiPediatric Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
Emilia RicciChild Neurology and Psychiatry Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
Duccio Maria CordelliChild Neurology and Psychiatry Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
Francesca LocatelliPathology Unit, Infermi Hospital, AUSL Romagna, Rimini, Italy.
Fabio CaramelliPediatric Intensive Care Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
Giovanna CenacchiDepartment of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy. giovanna.cenacchi@unibo.it.
University of Bologna · ITPoliclinico S.Orsola-Malpighi · ITIstituto Giannina Gaslini · ITOspedale Infermi di Rimini · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TORCH (Toxoplasmosis, Rubella, Cytomegalovirus, Herpes Simplex Virus and Syphilis) infections are a major cause of intrauterine and perinatal infections with associated morbidity and mortality. Neonatal Herpes Simplex Virus infection caused by an enveloped, double-stranded DNA virus of the Herpesviridae family is devastating and fatal. Herpes Viruses are not hepatotropic but may rarely cause hepatitis. Most cases of HSV hepatitis rapidly progress to fulminant hepatic failure and often fatal before the diagnosis or transplantation. Nowadays, despite the availability of antiviral treatment (acyclovir), the outcome remains poor because of late identification of hepatic Herpes Simplex Virus (HSV) infection. We report a male neonate suspected with a metabolic/mitochondrial disease and multi-organ involvement but who developed a fulminant hepatic failure and disseminated coagulopathy secondary to HSV type 1 (HSV-1) infection. The postmortem diagnosis was performed demonstrating HSV-1 in liver tissue by transmission electron microscopy and by retrospective detection of HSV specific antigens by immunohistochemistry.

Indexed as

Herpes SimplexHerpesvirus 1, HumanLiver Failure, AcuteMassive Hepatic NecrosisFemaleHumansInfant, NewbornMalePregnancyPregnancy Complications, InfectiousRetrospective StudiesElectron microscopyHepatitisHerpes simplexPostmorten diagnosisVirus

Identifiers

PMID34302289
OpenAlexW3185620147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.