SynthesisEuropean journal of clinical nutrition2022
Effect of early enteral nutrition combined with probiotics in patients with stroke: a meta-analysis of randomized controlled trials.
Synthesis in European journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Effects of Probiotic Supplementation on Core Symptoms of Autism Spectrum Disorder in Children.Nutrients · 2026Pooled it
- Pooled it
- Bifid triple viable preparation combined with enteral nutrition as a supportive treatment for acute ischemic stroke: a systematic review and meta-analysis.Frontiers in microbiology · 2024Pooled it
- Pooled it
- Effects of Melatonin in Original Rectal Suppositories on the Neurological Status and Mucosa-Associated and Luminal Microbiota of the Distal Colon in Wistar Rats with Experimental Acute Cerebral Ischemia.Bulletin of experimental biology and medicine · 2026Article
- A structured clinical nutrition pathway for enteral nutrition management in patients with intracerebral hemorrhage: a non-randomized controlled study.Frontiers in nutrition · 2026Article
- Potential synergistic effects of exercise and gut microbiota on post-stroke recovery: mechanistic insights and a proposed stage-specific research framework.Frontiers in cellular and infection microbiology · 2026Review
- Gut dysbiosis, metabolic signals, and pulmonary immune reprogramming: decoding the gut microbiota -immune axis in stroke-associated pneumonia.Frontiers in immunology · 2026Review
- Brain-gut communication and potential applications of microecological treatments in stroke.Frontiers in neuroscience · 2026Review
- A Comprehensive Review of the Role of the Microbiota-Gut-Brain Axis via Neuroinflammation: Advances and Therapeutic Implications for Ischemic Stroke.Biomolecules · 2025Review
- The Role of Oxidative Stress in Ischaemic Stroke and the Influence of Gut Microbiota.Antioxidants (Basel, Switzerland) · 2025Review
- Gastrointestinal Dysfunction and Dysbiosis in Ischemic Stroke: Opportunities for Therapeutic Intervention.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Predicting pneumonia algorithm in stroke patients.Frontiers in neurology · 2025Article
- Effect of sequential enteral nutrition support on elderly patients with severe ischemic stroke after thrombectomy.Frontiers in medicine · 2025Article
- Post-stroke depression: exploring gut microbiota-mediated barrier dysfunction through immune regulation.Frontiers in immunology · 2025Review
- Effects of enteral nutrition in stroke: an updated review.Frontiers in nutrition · 2025Review
- Gut Microbiome Modulation of Glutamate Dynamics: Implications for Brain Health and Neurotoxicity.Nutrients · 2024Review
- The clinical value of nutritional and inflammatory indicators in predicting pneumonia among patients with intracerebral hemorrhage.Scientific reports · 2024Article
- Research trends in nutritional interventions for stroke: a bibliometric analysis and literature review.Frontiers in nutrition · 2024Article
- Role of the gut microbiota in complications after ischemic stroke.Frontiers in cellular and infection microbiology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesWhether to conduct early enteral nutrition combined with probiotics (EEN/probiotics) in stroke patients remains controversial. This study was aimed to systematically explore the efficacy and safety of EEN/probiotics in stroke patients. SUBJECT/
methodsWe performed searches in EMBASE, PubMed, Medline, Cochrane Library, Chinese Biomedicine Literature Database (SinoMed), Chinese Scientific Journal Database (VIP), Chinese National Knowledge Infrastructure (CNKI) and Wanfang database.
resultsA total of 26 randomized controlled trials (2216 patients) were included. Meta-analysis showed a significantly lower incidence of gastrointestinal complications (%) (OR, 0.29; 95% CI,0.24-0.36; P < 0.00001), a lower incidence of infection (%) (OR, 0.27; 95% CI, 0.21-0.36; P < 0.00001), a shorter length of hospital stay (d) (MD, -8.70; 95% CI, -13.24 to -4.16; P = 0.003), and a lower dysbacteriosis rate (%) (OR, 0.17; 95% CI, 0.07-0.41; P < 0.0001) in the EEN/probiotics group than EEN group. Compared with EEN group, EEN/probiotics group had lower levels of diamine oxidase (U/L) (MD, -0.78; 95% CI, -0.93 to -0.63; P < 0.00001), D-lactic acid (mmol/L) (MD, -0.06; 95% CI, -0.07 to -0.05; P < 0.00001) and higher levels of albumin (g/L) (MD, 3.38; 95% CI, 2.74-4.02; P < 0.00001), prealbumin (mg/L) (MD, 32.20; 95% CI, 24.42-39.98; P < 0.00001), total protein (g/L) (MD, 4.91; 95% CI, 3.20-6.62; P < 0.00001), hemoglobin (g/L) (MD, 9.62; 95% CI, 7.92-11.32; P < 0.00001), immunoglobulin A (g/L) (MD, 0.23; 95% CI, 0.12-0.34; P < 0.0001) and immunoglobulin G (g/L) (MD, 0.33; 95% CI, 0.21-0.45; P < 0.00001).
conclusionEarly enteral nutrition combined with probiotics may effectively improve the nutritional status of stroke patients, regulate the intestinal flora and intestinal mucosal barrier function, improve the immune function, reduce the incidence of infectious complications and gastrointestinal motility disorders.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.