ArticleNature communications2021
Identification of 22 susceptibility loci associated with testicular germ cell tumors.
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In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
10.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Epidemiology and Risk Factors for Testicular Cancer: A Systematic Review.European urology · 2025Pooled it
- Association Study between Polymorphisms in DNA Methylation-Related Genes and Testicular Germ Cell Tumor Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Overlapping genetic etiology of pediatric and adult germ cell tumors.Journal of the National Cancer Institute · 2026Article
- Incidence, mortality and survival of testicular germ cell cancer in the province of Tarragona (Spain), 1980-2018.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Clinicopathological Features, Treatment Patterns, and Long-Term Survival in Patients With Testicular Cancer: A Retrospective Cohort Study.Cancer reports (Hoboken, N.J.) · 2026Article
- Uncovering novel germline variants associated with testicular germ cell tumors by exome sequencing.NAR cancer · 2026Article
- A novel polymorphism in the TERT gene is associated with lower survival in male patients with melanoma.Molecular medicine (Cambridge, Mass.) · 2026Article
- Association of Y-chromosomal gr/gr deletions with testicular germ cell tumor: whole-genome analysis of 198,306 individuals.medRxiv : the preprint server for health sciences · 2026Article
- The Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors.Andrology · 2026Article
- Integrated Bioinformatics Methods Were Employed to Investigate Potential Molecular Links Between Obstructive Sleep Apnea and Sarcoidosis.Mediators of inflammation · 2026Article
- From incidentaloma to actionable insight: a clinical-molecular-imaging framework for risk-stratified management of testicular microlithiasis.Frontiers in endocrinology · 2026Review
- Testicular Cancer: Diagnosis, Treatment, and Biomarker Advances.Research and reports in urology · 2026Review
- Testicular cancer in Latvia: incidence trends and prognostic outcomes across a 23-year study.BMC cancer · 2025Article
- Review
- A Thiopurine-like Mutagenic Process Defines TGCT Subtypes.bioRxiv : the preprint server for biology · 2025Article
- Article
- Identification of genes associated with testicular germ cell tumor susceptibility through a transcriptome-wide association study.American journal of human genetics · 2025Article
- Meta-analysis of Germline Whole-exome Sequencing in 1435 Cases of Testicular Germ Cell Tumour to Evaluate Disruptive Mutations Under Dominant, Recessive, and X-linked Inheritance Models.European urology open science · 2025Article
- High familial risks in some rare cancers may pinpoint to hidden germline genetics: focus on esophageal, stomach, small intestinal, testis, thyroid and bone cancers.Hereditary cancer in clinical practice · 2025Review
- Leveraging genome-wide association studies to better understand the etiology of cancers.Cancer science · 2025Review
Corrections and comments
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Authors and funding
57 authors at 20 institutions in 15 countries.
John PlutaDivision of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Louise C PyleDivision of Human Genetics, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8933-9320
Kevin T NeadDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-9680-8298
Rona WilfDivision of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mingyao LiDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8180-0621
Nandita MitraDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Benita WeathersDivision of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kurt D'AndreaDivision of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kristian AlmstrupDepartment of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-1832-0307
Lynn Anson-CartwrightDepartment of Surgery (Urology), University of Toronto and The Princess Margaret Cancer Centre, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-7726-9695
Javier BenitezHuman Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.
Christopher D BrownDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Stephen ChanockDivision of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2324-3393
Chu ChenProgram in Epidemiology, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Victoria K CortessisDepartments of Preventive Medicine and Obstetrics and Gynecology, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.
Alberto FerlinUnit of Endocrinology and Metabolism, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.ORCID http://orcid.org/0000-0002-0391-6570
Carlo ForestaUnit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-6576-2183
Marija GamulinDepartment of Oncology, Division of Medical Oncology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.ORCID http://orcid.org/0000-0003-2431-7910
Jourik A GietemaDepartment of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Chiara GrassoCancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte, Turin, Italy.ORCID http://orcid.org/0000-0002-2597-4990
Mark H GreeneDivision of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1852-9239
Tom GrotmolDepartment of Research, Cancer Registry of Norway, Oslo, Norway.ORCID http://orcid.org/0000-0001-5698-4350
Robert J HamiltonDepartment of Surgery (Urology), University of Toronto and The Princess Margaret Cancer Centre, Toronto, ON, Canada.
Trine B HaugenFaculty of Health Sciences, OsloMet-Oslo Metropolitan University, Oslo, Norway.ORCID http://orcid.org/0000-0002-8814-3393
Russ HauserDepartment of Environmental Health, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Michelle A T HildebrandtDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Matthew E JohnsonDivision of Human Genetics, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8949-2587
Lambertus A KiemeneyRadboud University Medical Center, Nijmegen, Netherlands.ORCID http://orcid.org/0000-0002-2368-1326
Davor LesselInstitute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0003-4496-244X
Ragnhild A LotheDepartment of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway.ORCID http://orcid.org/0000-0002-1693-1032
Jennifer T LoudDivision of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, Bethesda, MD, USA.
Chey LovedayDivision of Genetics & Epidemiology, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-2291-372X
Paloma Martin-GimenoHuman Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.
Coby MeijerDepartment of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Jérémie NsengimanaBiostatistics Research Group, Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.ORCID http://orcid.org/0000-0002-3603-4208
David I QuinnDivision of Oncology, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.
Thorunn RafnardeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-0491-7046
Shweta RamdasDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lorenzo RichiardiCancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte, Turin, Italy.ORCID http://orcid.org/0000-0003-0316-9402
Rolf I SkotheimDepartment of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway.ORCID http://orcid.org/0000-0002-5609-4048
Kari StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Clare TurnbullInstitute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-1734-5772
David J VaughnDivision of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4623-0544
Xifeng WuSchool of Public Health, Zhejiang University, Zhejiang, China.ORCID http://orcid.org/0000-0001-5174-3769
Daphne YangDivision of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Tongzhang ZhengDepartment of Epidemiology, Brown School of Public Health, Brown University, Providence, RI, USA.
Andrew D WellsCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Struan F A GrantDivision of Human Genetics, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2025-5302
Ewa Rajpert-De MeytsDepartment of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5946-7559
Stephen M SchwartzProgram in Epidemiology, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7499-8502
D Timothy BishopDepartment of Haematology and Immunology, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-8752-8785
Katherine A McGlynnDivision of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, Bethesda, MD, USA.
Peter A KanetskyDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-5567-9618
Katherine L NathansonDivision of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. knathans@upenn.edu.ORCID http://orcid.org/0000-0002-6740-0901
Testicular Cancer Consortium
University of Pennsylvania · USChildren's Hospital of Philadelphia · USNational Cancer Institute · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAdeCODE Genetics (Iceland) · ISKarolinska Institutet · SEOslo University Hospital · NOPiedmont Reference Center for Epidemiology and Cancer Prevention · ITRigshospitalet · DKSpanish National Cancer Research Centre · ESUniversität Hamburg · DEUniversity Medical Center Groningen · NLUniversity of Southern California · USUniversity of Toronto · CABrown University · USCancer Registry of Norway · NOHarvard University · USInstitute of Cancer Research · GBMoffitt Cancer Center · USNewcastle University · GB
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MUNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3MHormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5MTranslational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3MInstitutional Clinical and Translational Science AwardKL2TR001879 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$13.7MPost GWA Studies in Testicular Germ Cell TumorsU01CA164947 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KANETSKY, PETER A, NATHANSON, KATHERINE L. · 2012 to 2024
$11.7MMEDICAL GENETICS RESEARCH TRAINING GRANTT32GM008638 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca Ganetzky · 1997 to 2026
$8.7MMOLECULAR EPIDEMIOLOGY OF TESTICULAR CARCINOMAR01CA085914 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SCHWARTZ, STEPHEN M · 2000 to 2009
$8.4MEnvironment, Gene and Testicular Cancer RiskR01CA104786 · NCI · YALE UNIVERSITY · PI ZHENG, TONGZHANG · 2006 to 2010
$4.9MA Genetic Linkage Study of Testicular CancerR01CA102042 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CORTESSIS, VICTORIA K · 2004 to 2009
$3.9MNetwork-based algorithms for target identification and drug repositioning from genetic associationsR01HG010067 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI GREENE, CASEY S · 2018 to 2022
$3.2MInherited genetic variation and predisposition to testicular germ cell tumorR01CA114478 · NCI · UNIVERSITY OF PENNSYLVANIA · PI NATHANSON, KATHERINE L. · 2007 to 2011
$3.1MCancer Research UK 19167Cancer Research UK C588/A19167NCATS NIH HHS KL2 TR001879NCI NIH HHS K08 CA248704NCI NIH HHS N01 CN067009NCI NIH HHS N01 PC035142NCI NIH HHS P30 CA016520NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA085914NCI NIH HHS R01 CA102042NCI NIH HHS R01 CA104786NCI NIH HHS R01 CA114478NCI NIH HHS U01 CA164947NHGRI NIH HHS R01 HG010067NIEHS NIH HHS P30 ES013508NIGMS NIH HHS T32 GM008638Wellcome Trust
Abstract
Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and 179,683 men with and without TGCT, respectively, for a genome-wide association study. This meta-analysis identifies 22 TGCT susceptibility loci, bringing the total to 78, which account for 44% of disease heritability. Men with a polygenic risk score (PRS) in the 95
Indexed as
Polymorphism, Single NucleotideCell Line, TumorChromosome MappingGene Regulatory NetworksGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansLinkage DisequilibriumMaleMeta-Analysis as TopicNeoplasms, Germ Cell and EmbryonalProtein Interaction MapsTesticular Neoplasms
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