ArticleProceedings of the National Academy of Sciences of the United States of America2021
Three mutations repurpose a plant karrikin receptor to a strigolactone receptor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 40 citations in OpenAlex.
- Negative feedback regulation of karrikin signaling inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural and functional characterisation of a reconstructed ancestral strigolactone receptor.The Plant journal : for cell and molecular biology · 2026Article
- Evolutionary origin of neohesperidoside, a bitter metabolite, and its potential role in biotic defense and citrus dissemination.Plant communications · 2026Article
- Strigolactones and sesquiterpene lactones induce Orobanche cumana germination via KAI2d receptors through distinct processes.The Plant journal : for cell and molecular biology · 2026Article
- Molecular insights into volatile organic compound sensing and signaling in plants.The Plant journal : for cell and molecular biology · 2026Review
- Mechanistic basis for enhanced strigolactone sensitivity in KAI2 triple mutant.Biophysical journal · 2025Article
- Cracking the enigma: understanding strigolactone signalling in the rhizosphere.Journal of experimental botany · 2024Review
- Role of Strigolactones in the Host Specificity of Broomrapes and Witchweeds.Plant & cell physiology · 2023Review
- Structural analysis of a hormone-bound Striga strigolactone receptor.Nature plants · 2023Article
- Strigolactones: diversity, perception, and hydrolysis.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2023Article
- A KARRIKIN INSENSITIVE2 paralog in lettuce mediates highly sensitive germination responses to karrikinolide.Plant physiology · 2022Article
- A novel strigolactone receptor antagonist provides insights into the structural inhibition, conditioning, and germination of the crop parasite Striga.The Journal of biological chemistry · 2022Article
- Plant carotenoids: recent advances and future perspectives.Molecular horticulture · 2022Review
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uncovering the basis of small-molecule hormone receptors' evolution is paramount to a complete understanding of how protein structure drives function. In plants, hormone receptors for strigolactones are well suited to evolutionary inquiries because closely related homologs have different ligand preferences. More importantly, because of facile plant transgenic systems, receptors can be swapped and quickly assessed functionally in vivo. Here, we show that only three mutations are required to turn the nonstrigolactone receptor, KAI2, into a receptor that recognizes the plant hormone strigolactone. This modified receptor still retains its native function to perceive KAI2 ligands. Our directed evolution studies indicate that only a few keystone mutations are required to increase receptor promiscuity of KAI2, which may have implications for strigolactone receptor evolution in parasitic plants.
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