ArticleProceedings of the National Academy of Sciences of the United States of America2021
Wireless, battery-free, subdermally implantable platforms for transcranial and long-range optogenetics in freely moving animals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Crosstalk-free optical indicator-actuator combinations for bidirectional optogenetics.npj biomedical innovations · 2026Review
- Artifact-free, colocalized opto-electrophysiology enabled by a flexible, multimodal interface integrating transparent MXene microelectrodes and microLEDs.Biosensors & bioelectronics · 2026Article
- Wireless electrostimulation implants enable sphincter neuromuscular improvement toward mixed urinary incontinence.Nature communications · 2026Article
- "Tone-Arm" Neuromodulation MEMS Microcoil for In Vivo Imaging.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- The Training Village: an open platform for continuous testing of rodents in cognitive tasks.bioRxiv : the preprint server for biology · 2026Article
- Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Transcranial photobiomodulation with near-infrared laser induces analgesia in rats.The Journal of physiology · 2026Article
- Soft sonocapacitor with topologically integrated piezodielectric nanospheres enables wireless epidural closed-loop neuromodulation.Nature communications · 2026Article
- Patterned wireless transcranial optogenetics generates artificial perception.Nature neuroscience · 2026Article
- Far-field wireless power transmission module with MEMS-based laser steering for optogenetic applications.iScience · 2025Article
- A wireless optogenetic stimulation system for long-term function evaluation of mice forelimb with sub-nerve resolution.Nature communications · 2025Article
- Analysis and management of thermal loads generated in vivo by miniaturized optoelectronic implantable devices.Device · 2025Article
- Genetics-Based Targeting Strategies for Precise Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Design considerations for optogenetic applications of soft micro-LED-based device systems across diverse nervous systems.Bioactive materials · 2025Review
- Micro-Coil Neuromodulation at Single-Cell and Circuit Levels for Inhibiting Natural Neuroactivity, Neutralizing Electric Neural Excitation, and Suppressing Seizures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Continuous operation of battery-free implants enables advanced fracture recovery monitoring.Science advances · 2025Article
- Wireless Devices for Optical Brain Stimulation: A Review of Current Developments for Optogenetic Applications in Freely Moving Mice.Cellular and molecular bioengineering · 2025Review
- Centering cognitive neuroscience on task demands and generalization.Nature neuroscience · 2024Review
- Article
- Wireless magnetoelectrically powered organic light-emitting diodes.Science advances · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Wireless, battery-free, and fully subdermally implantable optogenetic tools are poised to transform neurobiological research in freely moving animals. Current-generation wireless devices are sufficiently small, thin, and light for subdermal implantation, offering some advantages over tethered methods for naturalistic behavior. Yet current devices using wireless power delivery require invasive stimulus delivery, penetrating the skull and disrupting the blood-brain barrier. This can cause tissue displacement, neuronal damage, and scarring. Power delivery constraints also sharply curtail operational arena size. Here, we implement highly miniaturized, capacitive power storage on the platform of wireless subdermal implants. With approaches to digitally manage power delivery to optoelectronic components, we enable two classes of applications: transcranial optogenetic activation millimeters into the brain (validated using motor cortex stimulation to induce turning behaviors) and wireless optogenetics in arenas of more than 1 m
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.