ArticleProceedings of the National Academy of Sciences of the United States of America2021
Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 59 citations in OpenAlex.
- Interactions Between Epidermal Growth Factor-Containing Fibulin-Like Extracellular Matrix Protein 1 and Tissue Inhibitor of Metalloproteinases-3 and Relevance to Age-Related Macular Degeneration.Ophthalmology science · 2026Review
- Single-Cell Gene Expression and eQTL Analyses in the Human Retina, RPE, and Choroid in Macular Degeneration.bioRxiv : the preprint server for biology · 2026Article
- NOTCH3 Pathogenic Variant and Risk of Age-Related Macular Degeneration: Findings From the Taiwan Biobank and Small Vessel Disease Registry.Investigative ophthalmology & visual science · 2026Article
- Review
- HTRA1-dependent proteolysis induces age-related retinal degeneration and exacerbates choroidal neovascularization.Disease models & mechanisms · 2025Article
- A spectrum of cysteine mutations in fibulin-3 highlight its disulfide bonding complexity and potential to induce ER stress.Scientific reports · 2025Article
- Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface.ACS chemical biology · 2025Article
- Epigenetic Alterations in Age-Related Macular Degeneration: Mechanisms and Implications.International journal of molecular sciences · 2025Review
- Genetic Associations of Rod- and Cone-Mediated Vision in Aging and Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2025Article
- Bruch's membrane heparan sulfate retains lipoproteins in the early stages of age-related macular degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dissecting the biological complexity of age-related macular degeneration: Is it one disease, multiple separate diseases, or a spectrum?Experimental eye research · 2025Review
- Role of alpha-1 antitrypsin in Bruch's membrane integrity.Scientific reports · 2025Article
- Article
- Human iPSC-based disease modeling studies identify a common mechanistic defect and potential therapies for AMD and related macular dystrophies.Developmental cell · 2024Article
- Exploring ocular fibulin-3 (EFEMP1): Anatomical, age-related, and species perspectives.Biochimica et biophysica acta. Molecular basis of disease · 2024Article
- Altered Elastin Turnover, Immune Response, and Age-Related Retinal Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1 Overexpression.Investigative ophthalmology & visual science · 2024Article
- Drug Approval for the Treatment of Geographic Atrophy: How We Got Here and Where We Need to Go.American journal of ophthalmology · 2024Review
- Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region.Nature communications · 2024Article
- Modeling complex age-related eye disease.Progress in retinal and eye research · 2024Review
- Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus.Investigative ophthalmology & visual science · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 2 institutions in 1 country.
Brandi L WilliamsSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132
Nathan A SeagerSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132
Jamie D GardinerSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132ORCID 0000-0001-9259-7403
Chris M PappasSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132
Monica C CroninSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132ORCID 0000-0001-9696-7512
Cristina Amat di San FilippoSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132
Robert A AnstadtSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132
Jin LiuSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132
Marc A TosoSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132
Lisa NicholsSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132
Timothy J ParnellBioinformatics Analysis, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132ORCID 0000-0002-3632-3691
Jacqueline R EveSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132ORCID 0000-0002-3159-5620
Sven HeinzDepartment of Medicine, University of California San Diego, La Jolla, CA 92093
Michael G B HayesDepartment of Medicine, University of California San Diego, La Jolla, CA 92093
Paul L BartelSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132ORCID 0000-0001-5470-6832
Moussa A ZouacheSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132ORCID 0000-0003-3689-7748
Burt T RichardsSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132ORCID 0000-0003-1789-2335
Gregory S HagemanSteele Center for Translational Medicine, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132ORCID 0000-0001-6360-829X
University of Utah · USUniversity of California San Diego · US
Funding
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6MDevelopment of Complement Modulating Therapeutics for AMDR24EY017404 · NEI · UNIVERSITY OF UTAH · PI HAGEMAN, GREGORY S · 2006 to 2010
$14.8MUniversity of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI PAUL STEVEN BERNSTEIN · 2005 to 2026
$14.6MNCI NIH HHS P30 CA042014NEI NIH HHS P30 EY014800NEI NIH HHS R24 EY017404
Abstract
Genome-wide association studies have identified the chromosome 10q26 (Chr10) locus, which contains the age-related maculopathy susceptibility 2 (
Indexed as
Genetic Predisposition to DiseaseChoroidGenetic VariationHigh-Temperature Requirement A Serine Peptidase 1HumansLinkage DisequilibriumMacular DegenerationRetinaRetinal Pigment EpitheliumRNA, MessengerHigh-Temperature Requirement A Serine Peptidase 1HTRA1 protein, humanRNA, Messengerage-related macular degenerationBruch’s membranecis-regulatory elementHTRA1retinal pigment epithelium
Identifiers
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.