ArticleProceedings of the National Academy of Sciences of the United States of America2021
An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Comparative genomic analysis reveals spine formation and coral prostaglandin tolerance in crown-of-thorns starfish.Fundamental research · 2026Article
- BMP signaling regulates dorsal skeletal growth in the sea urchin embryo.Development (Cambridge, England) · 2026Article
- Proton channels govern vesicular carbonate chemistry in mineralizing cells of a marine calcifier.Nature communications · 2026Article
- Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface.Nature communications · 2025Article
- Gene expression and enzyme activity analysis of carbohydrate digestion in Strongylocentrotus purpuratus larvae.The Journal of experimental biology · 2025Article
- Development of the semicircular canals and otolithic organs of the vertebrate inner ear.Current topics in developmental biology · 2025Review
- Bicarbonate-mediated proton transfer requires cations.Nature communications · 2024Article
- Structural mechanism of proton conduction in otopetrin proton channel.Nature communications · 2024Article
- Transcendent Aspects of Proton Channels.Annual review of physiology · 2024Review
- The proton channel OTOP1 is a sensor for the taste of ammonium chloride.Nature communications · 2023Article
- Mg-rich amorphous to Mg-low crystalline CaCOHeliyon · 2023Article
- Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus.eLife · 2023Article
- Vertebrate OTOP1 is also an alkali-activated channel.Nature communications · 2023Article
- Article
- Nematode homologs of the sour taste receptor Otopetrin1 are evolutionarily conserved acid-sensitive proton channels.Frontiers in cell and developmental biology · 2023Article
- Extracellular carbonic anhydrase activity promotes a carbon concentration mechanism in metazoan calcifying cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels.eLife · 2022Article
- Requirement for an Otopetrin-like protein for acid taste inProceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Otopetrins comprise a family of proton-selective channels that are critically important for the mineralization of otoliths and statoconia in vertebrates but whose underlying cellular mechanisms remain largely unknown. Here, we demonstrate that otopetrins are critically involved in the calcification process by providing an exit route for protons liberated by the formation of CaCO
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