ArticleLupus science & medicine2021
Characteristics of cardiovascular autonomic dysfunction and association with quality of life in patients with systemic lupus erythematosus.
Article in Lupus science & medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Diagnostic accuracy of the Arabic composite autonomic symptom score 31 (COMPASS-31) for detecting autonomic neuropathy in SLE: a cross-sectional validation study.Lupus science & medicine · 2026Article
- Ultrasound common hepatic artery denervation (CHA-D) as a novel neuromodulatory strategy for cardiovascular-kidney-metabolic syndrome: first-in-human experience.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Article
- Autonomic neuropathy is associated with an increase in type-1 cytokines in people living with HIV.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Autonomic Neuropathy Is Associated with An Increase in Type-1 Cytokines in People Living With HIV.bioRxiv : the preprint server for biology · 2025Article
- Recent advances in the diagnosis and management of neuropsychiatric lupus.Nature reviews. Rheumatology · 2024Review
- Vision-Related Quality of Life in Patients with Systemic Lupus Erythematosus.Healthcare (Basel, Switzerland) · 2024Article
- Myocardial fibrosis associates with lupus anticoagulant in patients with systemic lupus erythematosus.The international journal of cardiovascular imaging · 2024Article
- Article
- Assessment of autonomic dysfunction with the COMPASS-31 and its relationship with disease activity and cardiovascular risks in patients with psoriatic arthritis.Rheumatology international · 2022Observational
- Should Renal Inflammation Be Targeted While Treating Hypertension?Frontiers in physiology · 2022Review
- Characteristics of cardiovascular autonomic dysfunction and association with quality of life in patients with systemic lupus erythematosus.Lupus science & medicine · 2021Article
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Authors and funding
6 authors.
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Abstract
objectivesCardiovascular autonomic neuropathy (CAN) may affect the clinical course of SLE leading to reduced quality of life. CAN is assessed by heart rate variability (HRV) measures and cardiovascular autonomic reflex tests (CARTs). In patients with SLE, we aimed to determine the characteristics of CAN and if CAN associates with health-related quality of life (HRQoL).
methodsPatients with SLE and healthy controls (HCs) were CAN tested with 5 min HRV and three CARTs to determine parameters reflecting parasympathetic and mixed sympathetic-parasympathetic function. Subjects were classified as having no, early or definitive CAN by having none, one or more than one abnormal CART, respectively. HRQoL as determined by the Short Form 12 (SF-12) was assessed in SLE.
resultsOf 111 patients with SLE, 92 answered the SF-12 and 54 were matched with 54 HCs for characterisation of CAN. Definitive CAN was present in 24.1% (95% CI 15% to 37%) patients with SLE and 1.9% (95% CI 0.3% to 9.8%) HCs (OR 16.8, 95% CI 2.1 to 133.8, p=0.008). The corresponding prevalences of any CAN were 53.7% (95% CI 41% to 66%) and 22.6% (95% CI 13% to 35%). SLE patients with definitive CAN showed signs of mixed sympathetic-parasympathetic dysfunction, whereas patients without CAN primarily presented with impaired parasympathetic activity. Signs of parasympathetic as well as sympathetic-parasympathetic dysfunction were associated with low physical SF-12 component score (all: β>0.211, p<0.05). The mental SF-12 component score was not associated with any CAN indices.
conclusionsCAN was a frequent finding in SLE and associated to self-report on impaired physical HRQoL. Even patients without CAN showed signs of impaired parasympathetic function compared with controls.
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