Evidence map›Paper›PMID 34301818›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2021

Dysregulation of the Adaptive Immune System in Patients With Early-Stage Parkinson Disease.

Zhaoqi Yan, Wei Yang, Hairong Wei, Marissa N Dean, David G Standaert, Gary R Cutter, Etty N Benveniste, Hongwei Qin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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  6. Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhaoqi YanFrom the Department of Cell, Developmental and Integrative Biology (Z.Y., W.Y., H.W., E.N.B., H.Q.), Department of Neurology (M.N.D., D.G.S.), and Department of Biostatistics (G.R.C.), University of Alabama at Birmingham.
Wei YangFrom the Department of Cell, Developmental and Integrative Biology (Z.Y., W.Y., H.W., E.N.B., H.Q.), Department of Neurology (M.N.D., D.G.S.), and Department of Biostatistics (G.R.C.), University of Alabama at Birmingham.
Hairong WeiFrom the Department of Cell, Developmental and Integrative Biology (Z.Y., W.Y., H.W., E.N.B., H.Q.), Department of Neurology (M.N.D., D.G.S.), and Department of Biostatistics (G.R.C.), University of Alabama at Birmingham.
Marissa N DeanFrom the Department of Cell, Developmental and Integrative Biology (Z.Y., W.Y., H.W., E.N.B., H.Q.), Department of Neurology (M.N.D., D.G.S.), and Department of Biostatistics (G.R.C.), University of Alabama at Birmingham.
David G StandaertFrom the Department of Cell, Developmental and Integrative Biology (Z.Y., W.Y., H.W., E.N.B., H.Q.), Department of Neurology (M.N.D., D.G.S.), and Department of Biostatistics (G.R.C.), University of Alabama at Birmingham.ORCID 0000-0003-2921-8348
Gary R CutterFrom the Department of Cell, Developmental and Integrative Biology (Z.Y., W.Y., H.W., E.N.B., H.Q.), Department of Neurology (M.N.D., D.G.S.), and Department of Biostatistics (G.R.C.), University of Alabama at Birmingham.
Etty N BenvenisteFrom the Department of Cell, Developmental and Integrative Biology (Z.Y., W.Y., H.W., E.N.B., H.Q.), Department of Neurology (M.N.D., D.G.S.), and Department of Biostatistics (G.R.C.), University of Alabama at Birmingham.
Hongwei QinFrom the Department of Cell, Developmental and Integrative Biology (Z.Y., W.Y., H.W., E.N.B., H.Q.), Department of Neurology (M.N.D., D.G.S.), and Department of Biostatistics (G.R.C.), University of Alabama at Birmingham. hqin@uab.edu tika@uab.edu.ORCID 0000-0002-5453-8661
University of Alabama at Birmingham · US

Funding

Project 3: LRRK2 mediated macrophage responses in PDP50NS108675 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STANDAERT, DAVID G. · 2018 to 2022
$9.9M
ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
Therapeutic Intervention of the JAK/STAT Pathway for NeuroinflammationR01NS057563 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BENVENISTE, ETTY N · 2008 to 2017
$2.7M
NIAMS NIH HHS P30 AR048311NINDS NIH HHS P50 NS108675NINDS NIH HHS R01 NS057563
6 · The paper itself

Abstract

objectiveTo determine the activation status and cytokine profiles of CD4

methodsPeripheral blood samples from 41 patients with early-stage PD and 40 HCs were evaluated. Peripheral blood mononuclear cells were analyzed by flow cytometry for surface markers and intracellular cytokine production. Correlations of immunologic changes and clinical parameters were analyzed.

resultsAdaptive immunity plays a role in the pathogenesis of PD, yet the contribution of T cells and B cells, especially cytokine production by these cells, is poorly understood. We demonstrate that naive CD4

conclusionsThese findings suggest that alterations in the adaptive immune system may promote clinical disease in PD by skewing to a more proinflammatory state in the early-stage PD patient cohort. Our study may shed light on potential immunotherapies targeting dysregulated CD4

Indexed as

Adaptive ImmunityAdultAgedAged, 80 and overCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesFemaleHumansInflammation MediatorsLeukocytes, MononuclearMaleMiddle AgedParkinson DiseaseCytokinesInflammation Mediators

Identifiers

PMID34301818
PMCPMC8299515
OpenAlexW3186606674

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.