ArticleJournal of epidemiology and community health2022
Uterine fibroids and incidence of depression, anxiety and self-directed violence: a cohort study.
Article in Journal of epidemiology and community health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Pooled it
- The impact of fibroid treatments on quality of life and mental health: a systematic review.Fertility and sterility · 2024Pooled it
- A logistic regression model for predicting postoperative recurrence of cellular uterine leiomyoma.European journal of obstetrics & gynecology and reproductive biology: X · 2026Article
- Emulating a target trial of surgical removal of uterine fibroids on atherosclerotic cardiovascular disease.Fertility and sterility · 2026Article
- Association of GnRH agonists with depression and suicide/self-injury: a FAERS pharmacovigilance study.Endocrine connections · 2026Article
- The Invisible Burden: Examining the Impact of Exposure Misclassification in Epidemiologic Analyses of Uterine Fibroids.Paediatric and perinatal epidemiology · 2026Article
- Association Between Uterine Fibroids and Risk of Atherosclerotic Cardiovascular Disease.Journal of the American Heart Association · 2026Article
- Engagement with WeChat-Based Remote Psychological Counseling and Patient-Reported Outcomes After Uterine Artery Embolization in China: A Retrospective Cohort Study.Psychology research and behavior management · 2026Article
- The Impact of Rosenthal Effect-Based Psychological Nursing on Psychological State, Self-Efficacy, and Quality of Life in Patients Undergoing Total Hysterectomy for Uterine Fibroids: A Randomized Controlled Trial.International journal of women's health · 2026Article
- Navigating the future landscape of uterine fibroid research: a comprehensive summary of patient-centered outcome measures and implications.BMC women's health · 2025Article
- 'The disease ruined my life': a qualitative study of the quality of life in women with uterine fibroids.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- The integrative health status of women with uterine fibroids wishing to maintain fertility: a cross-sectional study based on Levine's conservation model.Women's health nursing (Seoul, Korea) · 2025Article
- Suicide by Firearm and Hormonal Imbalances: A Forensic Case Report With Literature Review.Cureus · 2025Article
- Association between olanzapine and immune function in lung cancer patients with anxiety and depression: a retrospective cohort study of medical records.Frontiers in psychiatry · 2025Article
- Increased incidence of uterine leiomyoma in young females with depression: An observational study.iScience · 2024Article
- Familial coaggregation and shared genetic influence between major depressive disorder and gynecological diseases.European journal of epidemiology · 2024Article
- Predicting nutrition and environmental factors associated with female reproductive disorders using a knowledge graph and random forests.International journal of medical informatics · 2024Article
- Psychological distress and uterine fibroids: a bidirectional two-sample mendelian randomization study.BMC women's health · 2024Article
- Hypoxia in uterine fibroids: role in pathobiology and therapeutic opportunities.Oxygen (Basel, Switzerland) · 2024Article
- The experiences of women diagnosed with uterine fibroids in the Kingdom of Eswatini.Health SA = SA Gesondheid · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression and anxiety are prevalent among women with uterine fibroids (UF). The rate of mental health diagnoses in women with UF has not been studied.
methodsWomen aged 18-50 years with diagnosed UF were identified in the Optum Clinformatics commercial insurance claims database (OptumInsight, Eden Prairie, Minnesota) from 1 May 2000 to 31 March 2020 (n=313 754) and were matched 1:2 on age and calendar time to women without (n=627 539). Cox proportional hazards models estimated HRs and 95% CIs between UF and diagnosed depression, anxiety and self-directed violence, adjusting for demographics and comorbidities. Among women with diagnosed UF, the association between hysterectomy and mental health outcomes was estimated.
resultsAfter adjusting for confounders, women with diagnosed UF had a higher rate of depression (HR: 1.12; 95% CI 1.10 to 1.13), anxiety (HR: 1.12; 95% CI 1.10 to 1.13) and self-directed violence (HR: 1.46; 95% CI 1.29 to 1.64) than women without. Among women with pain symptoms and heavy menstrual bleeding, the HR comparing women with diagnosed UF to women without was 1.21 (95% CI 1.18 to 1.25) for depression, 1.18 (95% CI 1.15 to 1.21) for anxiety and 1.68 (95% CI 1.35 to 2.09) for self-directed violence. Among women with diagnosed UF, the HR comparing women who underwent a hysterectomy to women who did not was 1.22 (95% CI 1.17 to 1.27) for depression, 1.13 (95% CI 1.09 to 1.17) for anxiety and 1.86 (95% CI 1.39 to 2.49) for self-directed violence.
conclusionsRates of depression, anxiety and self-directed violence were higher among women with diagnosed UF, particularly among those who experienced pain symptoms or who underwent hysterectomy.
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